ArticleAmerican journal of respiratory cell and molecular biology2010
Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.
Article in American journal of respiratory cell and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Effects of exercise training on airway hyperreactivity in asthma: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2013Pooled it
- Effect of physical training on airway inflammation in animal models of asthma: a systematic review.BMC pulmonary medicine · 2013Pooled it
- Regular exercise improves asthma control in adults: A randomized controlled trial.Scientific reports · 2019Trial
- The effects of exercise training in a weight loss lifestyle intervention on asthma control, quality of life and psychosocial symptoms in adult obese asthmatics: protocol of a randomized controlled trial.BMC pulmonary medicine · 2015Trial
- Aerobic exercise alleviates allergic airway inflammation by suppressingNon-coding RNA research · 2025Article
- Impact of physical and psychological stressors on tumor growth and immune responses in breast cancer.Comprehensive psychoneuroendocrinology · 2025Article
- Exercise Recommendations and Practical Considerations for Asthma Management-An EAACI Position Paper.Allergy · 2025Article
- Association of lung health and cardiovascular health (Life's Essential 8).Frontiers in medicine · 2025Article
- Association between adherence to a lifestyle behavior and the risk of asthma in overweight and obese adolescents.BMC pediatrics · 2024Article
- Asthma: An Untoward Consequence of Endurance Sports?American journal of respiratory cell and molecular biology · 2020Article
- Physical Activity: A Missing Link in Asthma Care.Journal of clinical medicine · 2020Review
- Miso (Fermented Soybean Paste) Suppresses Visceral Fat Accumulation in Mice, Especially in Combination with Exercise.Nutrients · 2019Article
- Diet and Metabolism in the Evolution of Asthma and Obesity.Clinics in chest medicine · 2019Review
- Anti-oxidant and Anti-inflammatory Effects of Aquatic Exercise in Allergic Airway Inflammation in Mice.Frontiers in physiology · 2019Article
- Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice.Scientific reports · 2018Article
- Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway.Frontiers in immunology · 2016Article
- Intensity of swimming exercise influences tracheal reactivity in rats.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2015Article
- Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Obesity in asthma: approaches to treatment.Current allergy and asthma reports · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have reported that moderate-intensity aerobic exercise training attenuates airway inflammation in mice sensitized/challenged with ovalbumin (OVA). The current study determined the effects of repeated bouts of aerobic exercise at a moderate intensity on airway hyperresponsiveness (AHR) in these mice. Mice were sensitized/challenged with OVA or saline and exercised at a moderate intensity 3 times/week for 4 weeks. At protocol completion, mice were analyzed for changes in AHR via mechanical ventilation. Results show that exercise decreased total lung resistance 60% in OVA-treated mice as compared with controls; exercise also decreased airway smooth muscle (ASM) thickness. In contrast, exercise increased circulating epinephrine levels 3-fold in saline- and OVA-treated mice. Because epinephrine binds beta(2)-adrenergic receptors (AR), which facilitate bronchodilatation, the role of beta(2)-AR in exercise-mediated improvements in AHR was examined. Application of the beta(2)-AR antagonist butoxamine HCl blocked the effects of exercise on lung resistance in OVA-treated mice. In parallel, ASM cells were examined for changes in the protein expression of beta(2)-AR and G-protein receptor kinase-2 (GRK-2); GRK-2 promotes beta(2)-AR desensitization. Exercise had no effect on beta(2)-AR expression in ASM cells of OVA-treated mice; however, exercise decreased GRK-2 expression by 50% as compared with controls. Exercise also decreased prostaglandin E(2) (PGE(2)) production 5-fold, but had no effect on E prostanoid-1 (EP1) receptor expression within the lungs of OVA-treated mice; both PGE(2) and the EP1 receptor have been implicated in beta(2)-AR desensitization. Together, these data indicate that moderate-intensity aerobic exercise training attenuates AHR via a mechanism that involves beta(2)-AR.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.