ArticleEndocrinology2009
The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 80 citations in OpenAlex.
- Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox Signaling and Disease Development.International journal of molecular sciences · 2025Review
- The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.The Journal of clinical endocrinology and metabolism · 2025Review
- Current Insights in Prolactin Signaling and Ovulatory Function.International journal of molecular sciences · 2024Review
- Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current.Frontiers in cellular neuroscience · 2024Article
- Article
- Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice.Hormones and behavior · 2022Article
- Current Perspectives on Kisspeptins Role in Behaviour.Frontiers in endocrinology · 2022Review
- Kisspeptin modulates gamma-aminobutyric acid levels in the human brain.Psychoneuroendocrinology · 2021Article
- The anti-dipsogenic and anti-natriorexigenic effects of estradiol, but not the anti-pressor effect, are lost in aged female rats.Physiological reports · 2021Article
- Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity.Scientific reports · 2020Article
- Article
- Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice.Neuroendocrinology · 2019Article
- GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.Reproductive biology and endocrinology : RB&E · 2018Article
- Gamma-aminobutyric acidReproductive medicine and biology · 2017Article
- The Role of Kisspeptin in Female Reproduction.International journal of endocrinology and metabolism · 2017Review
- Article
- Kisspeptin signaling in the amygdala modulates reproductive hormone secretion.Brain structure & function · 2016Article
- Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1.Journal of assisted reproduction and genetics · 2016Article
- The Role of RFamide-Related Peptide-3 in Age-Related Reproductive Decline in Female Rats.Frontiers in endocrinology · 2016Article
- Evidence for Changes in Numbers of Synaptic Inputs onto KNDy and GnRH Neurones during the Preovulatory LH Surge in the Ewe.Journal of neuroendocrinology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Reproductive success depends on a robust and appropriately timed preovulatory LH surge. The LH surge, in turn, requires ovarian steroid modulation of GnRH neuron activation by the neuropeptide kisspeptin and glutamate and gamma-aminobutyric acid (GABA) neurotransmission in the medial preoptic area (mPOA). Middle-aged females exhibit reduced excitation of GnRH neurons and attenuated LH surges under estrogen-positive feedback conditions, in part, due to increased GABA and decreased glutamate neurotransmission in the mPOA. This study tested the hypothesis that altered kisspeptin regulation by ovarian steroids plays a role in age-related LH surge dysfunction. We demonstrate that middle-aged rats exhibiting delayed and attenuated LH surges have reduced levels of Kiss1 mRNA in the anterior hypothalamus under estrogen-positive feedback conditions. Kisspeptin application directly into the mPOA rescues total LH release and the LH surge amplitude in middle-aged rats and increases glutamate and decreases GABA release to levels seen in the mPOA of young females. Moreover, the N-methyl-D-aspartate receptor antagonist MK801 blocks kisspeptin reinstatement of the LH surge. These observations suggest that age-related LH surge dysfunction results, in part, from reduced kisspeptin drive under estrogen-positive feedback conditions and that kisspeptin regulates GnRH/LH release, in part, through modulation of mPOA glutamate and GABA release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.