ArticleJournal of the American Society of Nephrology : JASN2009
Functional TauT protects against acute kidney injury.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Plasma metabolomics analysis in murine prerenal azotemia reveals changes in energy substrates, amino acid metabolism, and uremic toxins.American journal of physiology. Renal physiology · 2026Article
- Molecular mechanisms attributed to colistin renal proximal tubular epithelial cytotoxicity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Review
- Molecular basis for substrate recognition and transport of mammalian taurine transporters.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Direct Three-Dimensional Mass Spectrometry Imaging with Laser Ablation Remote Atmospheric Pressure Photoionization/Chemical Ionization.Analytical chemistry · 2024Article
- Article
- Metabolomics Assessment of Volume Overload-Induced Heart Failure and Oxidative Stress in the Kidney.Metabolites · 2023Article
- Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients.Scientific reports · 2023Article
- TMT-based proteomics analysis of the cerebral cortex of TauT knockout rats.Proteome science · 2022Article
- Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models.Antioxidants (Basel, Switzerland) · 2021Review
- Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression.BioMed research international · 2021Article
- Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review).International journal of oncology · 2020Review
- Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).Molecular medicine reports · 2020Review
- Protective effect of avenanthramides against cisplatin induced nephrotoxicity in rats.Journal of advanced veterinary and animal research · 2019Article
- Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Protective effects of zingerone on cisplatin-induced nephrotoxicity in female rats.Environmental science and pollution research international · 2019Article
- Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Review
- Beneficial Effects ofJournal of the American Society of Nephrology : JASN · 2017Article
- miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA.Virology journal · 2017Article
- Effect of taurine on intestinal recovery following intestinal ischemia-reperfusion injury in a rat.Pediatric surgery international · 2016Article
- Knockout of the TauT gene predisposes C57BL/6 mice to streptozotocin-induced diabetic nephropathy.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrotoxicity is common with the use of the chemotherapeutic agent cisplatin, but the cellular mechanisms that modulate the extent of injury are unknown. Cisplatin downregulates expression of the taurine transporter gene (TauT) in LLC-PK1 proximal tubular renal cells, and forced overexpression of TauT protects against cisplatin-induced apoptosis in vitro. Because the S3 segments of proximal tubules are the sites of both cisplatin-induced injury and adaptive regulation of the taurine transporter, we hypothesized that TauT functions as an anti-apoptotic gene and protects renal cells from cisplatin-induced nephrotoxicity in vivo. Here, we studied the regulation of TauT in cisplatin nephrotoxicity in a human embryonic kidney cell line and in LLC-PK1 cells, as well as in TauT transgenic mice. Cisplatin-induced activation of p53 repressed TauT and overexpression of TauT prevented the progression of cisplatin-induced apoptosis and renal dysfunction in TauT transgenic mice. Although cisplatin activated p53 and PUMA (a p53-responsive proapoptotic Bcl-2 family protein) in the kidneys of both wildtype and TauT transgenic mice, only wildtype animals demonstrated acute kidney injury. These data suggest that functional TauT plays a critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway.
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