Evidence map›Paper›PMID 19423393›Full record

ArticleTrends in parasitology2009

varDB: common ground for a shifting landscape.

David R Allred, Anthony F Barbet, J David Barry, Kirk W Deitsch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David R AllredDepartment of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611, USA. allredd@vetmed.ufl.edu
Anthony F Barbet
J David Barry
Kirk W Deitsch

Funding

Var gene regulation and antigenic variation in malariaR01AI052390 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2002 to 2019
$6.6M
Evolution of chronic infection in Anasplasma phagocytophilumR01GM081714 · NIGMS · UNIVERSITY OF FLORIDA · PI BARBET, ANTHONY F. · 2007 to 2010
$1.7M
Mechanisms controlling babesial antigenic variationR01AI055864 · NIAID · UNIVERSITY OF FLORIDA · PI ALLRED, DAVID R. · 2004 to 2008
$1.4M
NIAID NIH HHS R01 AI052390NIAID NIH HHS R01 AI055864NIGMS NIH HHS R01 GM081714Wellcome Trust
6 · The paper itself

Abstract

Antigenic variation is a phylogenetically widespread phenomenon thought to lead to survival benefits for the pathogen. Although governed by genetic mechanisms, antigenic variation is ultimately manifested in variant proteins. The varDB database is an attempt to gain an overview of common structures and functions of variant proteins related to enhanced survival. varDB provides a wealth of sequence data and several tools to facilitate their analysis, but current limitations preclude achievement of its full promise. A critique of this database and how it could serve the scientific community is provided here.

Indexed as

Antigenic VariationDatabases, ProteinAnimalsBacteriaDatabases, GeneticEukaryotaFungiHIVHumansProteinsStructure-Activity RelationshipProteins

Identifiers

PMID19423393
PMCPMC3697053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.