ArticleEuropean journal of pain (London, England)2010
Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.
Article in European journal of pain (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- The Efficacy and Safety of Dexmedetomidine for Procedural Sedation in Patients Receiving Local Anesthesia Outside the Intensive Care Unit: A Prospective, Double-Blind, Randomized Clinical Phase III Trial in Japan.Yonago acta medica · 2022Article
- Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain.International journal of molecular sciences · 2021Article
- Ethnic differences in genetic polymorphism associated with irritable bowel syndrome.World journal of gastroenterology · 2020Review
- Analysis of the source of aggressiveness in gamecocks.Scientific reports · 2020Article
- Effect of ADRA2A gene polymorphisms on the anesthetic and analgesic effects of dexmedetomidine in Chinese Han women with cesarean section.Experimental and therapeutic medicine · 2020Article
- Relationship between genetic variation in the αJournal of Zhejiang University. Science. B · 2019Article
- The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women.Menopause (New York, N.Y.) · 2019Article
- Variation in the αPharmacogenomics · 2017Article
- Genetic variation in the alphaThe pharmacogenomics journal · 2017Article
- Article
- Interpatient variability in dexmedetomidine response: a survey of the literature.TheScientificWorldJournal · 2014Review
- A general linear model-based approach for inferring selection to climate.BMC genetics · 2013Article
- Variation in the α(2A) adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose.Pharmacogenetics and genomics · 2013Article
- [Dexmedetomidine. Pharmacokinetics and pharmacodynamics].Der Anaesthesist · 2012Review
- Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study.Journal of pharmacokinetics and pharmacodynamics · 2011Article
- The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery.Molecular biology reports · 2011Article
- Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.Pharmacogenetics and genomics · 2011Article
- Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine.Circulation. Cardiovascular genetics · 2011Article
- Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis.Biology of reproduction · 2011Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe mechanisms underlying interindividual variability in pain perception and cognitive responses are undefined but highly heritable. alpha(2C)- and alpha(2A)-adrenergic receptors regulate noradrenergic activity and are important mediators of pain perception and analgesia. We hypothesized that common genetic variants in these genes, particularly the ADRA2C 322-325 deletion variant, affect pain perception or cognitive responses.
methodsWe studied 73 healthy subjects (37 Caucasians and 36 African-Americans) aged 25.4+/-4.6years. Pain response to a cold pressor test was measured using a 10cm visual analog scale and again on the next day, after three infusions of the selective alpha(2)-agonist dexmedetomidine. Standardized cognitive tests were administered at baseline and after each infusion. The contribution of ADRA2C deletion genotype, dexmedetomidine concentration, and other covariates to pain perception and cognitive responses was determined using multiple linear regression models. Secondary analysis examined the effects of ADRA2A and other ADRA2C variants on pain perception.
resultsADRA2C Del homozygotes had higher pain scores in response to cold at baseline (6.3+/-1.8cm) and after dexmedetomidine (5.6+/-2.2cm) than insertion allele carriers (4.6+/-2.1cm [baseline] and 3.8+/-1.9cm [after dexmedetomidine]; adjusted P-values=0.019 and 0.004, respectively). Cognitive responses were unrelated to ADRA2C Ins/Del genotype. None of the other ADRA2A and ADRA2C variants was significantly related to cold pain sensitivity before dexmedetomidine; after dexmedetomidine, ADRA2A rs1800038 was marginally associated (P=0.03).
conclusionThe common ADRA2C del322-325 variant affected pain perception before and after dexmedetomidine but did not affect other cognitive responses, suggesting that it contributes to interindividual variability in pain perception.
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