ArticleBurns : journal of the International Society for Burn Injuries2009
Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing.
Article in Burns : journal of the International Society for Burn Injuries, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Evaluation of Laser Speckle Contrast Imaging for the Assessment of Oral Mucosal Blood Flow following Periodontal Plastic Surgery: An Exploratory Study.BioMed research international · 2017Trial
- Assessing the Wound Healing Efficacy of Wrightia tinctoria Protease-Hydrolysed Cobia Skin Collagen: An In Vivo and In Silico Study.Applied biochemistry and biotechnology · 2026Article
- Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Conditioned plasma promotes full-thickness skin defect healing in a rat model.Regenerative therapy · 2025Article
- Vascular leakage and angiogenesis in wound healing: a review.Molecular biology reports · 2025Review
- Wound healing induced by new synthetic peptide, A7-1, in C57BL/6 mouse model.Biomedical engineering online · 2024Article
- Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Angiogenic Modification of Microfibrous Polycaprolactone by pCMV-VEGF165 Plasmid Promotes Local Vascular Growth after Implantation in Rats.International journal of molecular sciences · 2023Article
- SDF-1α gene-activated collagen scaffold enhances provasculogenic response in a coculture of human endothelial cells with human adipose-derived stromal cells.Journal of materials science. Materials in medicine · 2021Article
- Fluorescent light energy modulates healing in skin grafted mouse model.Open medicine (Warsaw, Poland) · 2021Article
- Vascularization is the next challenge for skin tissue engineering as a solution for burn management.Burns & trauma · 2020Review
- Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin.Shock (Augusta, Ga.) · 2016Article
- Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing.PloS one · 2015Article
- A full skin defect model to evaluate vascularization of biomaterials in vivo.Journal of visualized experiments : JoVE · 2014Article
- The candidate tumor suppressor gene Ecrg4 as a wound terminating factor in cutaneous injury.Archives of dermatological research · 2013Article
- Vagus nerve stimulation blocks vascular permeability following burn in both local and distal sites.Burns : journal of the International Society for Burn Injuries · 2013Article
- Evaluation of electrospun (1,3)-(1,6)-β-D-glucans/biodegradable polymer as artificial skin for full-thickness wound healing.Tissue engineering. Part A · 2012Article
- Skin graft vascular maturation and remodeling: a multifractal approach to morphological quantification.Microcirculation (New York, N.Y. : 1994) · 2012Article
- In vivo laser speckle imaging reveals microvascular remodeling and hemodynamic changes during wound healing angiogenesis.Angiogenesis · 2012Article
- A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices.Fibrogenesis & tissue repair · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The use of engineered tissue for the treatment of a variety of acute to chronic wounds has become a clinical standard, and a better understanding of the cellular mechanisms of re-vascularization and barrier integrity could enhance clinical outcomes. Here, we focus on the characterization of the re-vascularization of acellular grafts such as Integra in an animal model to better understand the physiological properties of blood vessels growing in the collagen-glycosaminoglycan matrix vs. wound margins. While Integra has been extensively studied in pre-clinical models, the re-modeling mechanisms of the capillary bed under these matrices are not well understood. Therefore, our first objective was to quantify the kinetics of re-vascularization. The second objective was to assess changes in vascular permeability (VP) of the wound bed compared to normal adjacent skin. The third objective was to establish a non-invasive and quantitative assay for the measurement of VP to facilitate the rapid and reproducible characterization of vascular integrity. Using an excisional wound model in mice, we characterize the appearance, growth, and maturation of blood vessels in an Integra graft over 28 days after surgery. Initial appearance of blood vessels in the graft was observed at 7 days, with angiogenesis peaking between 7 and 14 days. The onset of VP coincided with the increase in re-vascularization of the wound bed and there was a sustained elevation of VP that declined to baseline by 28 days. We propose a non-invasive strategy to assess VP of the wound capillary bed will facilitate a better understanding of the cell and molecular basis of angiogenesis in wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.