Trial reportPain2009
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.
Trial report in Pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03096444 (Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine), which is not on this map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine
Who cites it
84 citing papers in PubMed, 158 citations in OpenAlex.
- Trial
- Sensory responses to injection and punctate application of capsaicin and histamine to the skin.Pain · 2011Trial
- Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.PloS one · 2011Trial
- Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP.The journal of headache and pain · 2010Trial
- Safety Assessment of the Ethanolic Seed Extract ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Affective touch reduces histamine evoked itch experience.PloS one · 2025Article
- The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome.Cell reports · 2024Article
- Peripheral signaling pathways contributing to non-histaminergic itch in humans.Journal of translational medicine · 2023Article
- Pruritus and urticaria induced by neurostimulation: A case report and review of literature.Surgical neurology international · 2023Article
- How Does Botulinum Toxin Inhibit Itch?Toxins · 2022Review
- Evaluation of itch and pain induced by bovine adrenal medulla (BAM)8-22, a new human model of non-histaminergic itch.Experimental dermatology · 2022Article
- Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.International journal of molecular sciences · 2022Article
- Effects of Salicornia-Based Skin Cream Application on Healthy Humans' Experimental Model of Pain and Itching.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Interactions of the Neuro‒Immune‒Stromal Triad in Itch.The Journal of investigative dermatology · 2022Review
- A neuropeptide code for itch.Nature reviews. Neuroscience · 2021Review
- Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review.Dermatology and therapy · 2021Review
- Article
- TRPV1 in Pain and Itch.Advances in experimental medicine and biology · 2021Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Itch evoked by cowhage or histamine is reduced or blocked by capsaicin desensitization, suggesting that pruriceptive neurons are capsaicin-sensitive. Topical capsaicin can evoke both nociceptive sensations and itch, whereas intradermal injection of capsaicin evokes only burning pain. To dissociate the pruritic and nociceptive sensory effects caused by the chemical activation of sensory neurons, chemicals were applied in a punctiform manner to the skin of the forearm using individual, heat-inactivated cowhage spicules treated with various concentrations of capsaicin (1-200 mg/ml) or histamine (0.01-100 mg/ml). Perceived intensities of itch, pricking/stinging and burning were obtained every 30 s using the general version of the Labeled Magnitude Scale and compared with ratings evoked by individual native cowhage spicules. Similar to cowhage, capsaicin and histamine spicules reliably evoked sensations of itch in a dose-dependent manner which were most often accompanied by pricking/stinging and to a lesser extent burning. Spicules containing 200 mg/ml capsaicin or 10 mg/ml histamine yielded peak magnitudes and durations of sensations comparable to those elicited by cowhage. Each type of spicule also produced comparable areas of dysesthesias (enhanced mechanically evoked itch or pain) and/or skin reactions (wheal and/or flare) in surrounding skin, though inconsistently. The incidence of flare was greater in response to histamine than to capsaicin or cowhage. These results suggest the possibility that capsaicin, histamine and cowhage activate common peripheral or central neural mechanisms that mediate pruritic sensations and associated dysesthesias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.