ArticleHearing research2009
Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament.
Article in Hearing research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Pericytes and Diabetic Microangiopathies: Tissue Resident Mesenchymal Stem Cells with High Plasticity and Regenerative Capacity.International journal of molecular sciences · 2025Review
- Impact of NA-1 on Pericyte-Driven Vasoconstriction and Its Role in No-Reflow During Cerebral Ischemia-Reperfusion.CNS neuroscience & therapeutics · 2025Article
- Research advances in cochlear pericytes and hearing loss.Hearing research · 2023Review
- Molecular Mechanisms Underlying Pathological and Therapeutic Roles of Pericytes in Atherosclerosis.International journal of molecular sciences · 2022Review
- Regulation of Endothelial Nitric Oxide Synthase in the Reticular Lamina of the Organ of Corti by a Nitric Oxide Donor.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Article
- Review
- Acoustic Trauma Causes Cochlear Pericyte-to-Myofibroblast-Like Cell Transformation and Vascular Degeneration, and Transplantation of New Pericytes Prevents Vascular Atrophy.The American journal of pathology · 2020Article
- The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice.Scientific reports · 2020Article
- Research advances in pericyte function and their roles in diseases.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2020Review
- Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse BrainFrontiers in aging neuroscience · 2020Article
- Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss.International journal of molecular sciences · 2019Article
- Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion.Acta neuropathologica communications · 2019Article
- Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.American journal of physiology. Heart and circulatory physiology · 2019Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier.Science translational medicine · 2019Review
- Advances and Challenges in Pharmaceutical Therapies to Prevent and Repair Cochlear Injuries From Noise.Frontiers in cellular neuroscience · 2019Review
- Active role of capillary pericytes during stimulation-induced activity and spreading depolarization.Brain : a journal of neurology · 2018Article
- Electrophysiological properties of strial pericytes and the effect of aspirin on pericyte K+ channels.Molecular medicine reports · 2018Article
- In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes.Proteome science · 2018Article
- Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Pericytes, mural cells located on microvessels, are considered to play an important role in the formation of the vasculature and the regulation of local blood flow in some organs. Little is known about the physiology of cochlear pericytes. In order to investigate the function of cochlear pericytes, we developed a method to visualize cochlear pericytes using diaminofluorescein-2 diacetate (DAF-2DA) and intravital fluorescence microscopy. This method can permit the study of the effect of vasoactive agents on pericytes under the in vivo and normal physiological condition. The specificity of the labeling method was verified by the immunofluorescence labeling of pericyte maker proteins such as desmin, neural proteoglycan (NG2), and thymocyte differentiation antigen 1 (Thy-1). Superfused K(+) and Ca(2+) to the cochlear lateral wall resulted in localized constriction of capillaries at pericyte locations both in vivo and in vitro, while there was no obvious change in cochlear capillary diameters with application of the adrenergic neurotransmitter noradrenaline. The method could be an effective way to visualize cochlear pericytes and microvessels and study lateral wall vascular physiology. Moreover, we demonstrate for the first time that cochlear pericytes have contractility, which may be important for regulation of cochlear blood flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.