ArticleBMC bioinformatics2009
CURE-Chloroplast: a chloroplast C-to-U RNA editing predictor for seed plants.
Article in BMC bioinformatics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Bibliometric Study for Plant RNA Editing Research: Trends and Future Challenges.Molecular biotechnology · 2023Review
- RNA Editing in Chloroplast: Advancements and Opportunities.Current issues in molecular biology · 2022Review
- Comprehensive analysis of chloroplast genome of Albizia julibrissin Durazz. (Leguminosae sp.).Planta · 2021Article
- Complete chloroplast genome of the medicinal plantPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Detection and Analysis of C-to-U RNA Editing in Rice Mitochondria-Encoded ORFs.Plants (Basel, Switzerland) · 2020Article
- Systematic analysis reveals cis and trans determinants affecting C-to-U RNA editing in Arabidopsis thaliana.BMC genetics · 2020Article
- The chloroplast and mitochondrial C-to-U RNA editing inPlant direct · 2019Article
- The Complete Chloroplast Genome Sequences of the Medicinal Plant Forsythia suspensa (Oleaceae).International journal of molecular sciences · 2017Article
- RNA editing and drug discovery for cancer therapy.TheScientificWorldJournal · 2013Review
- PREPACT 2.0: Predicting C-to-U and U-to-C RNA Editing in Organelle Genome Sequences with Multiple References and Curated RNA Editing Annotation.Bioinformatics and biology insights · 2013Article
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- RESOPS: a database for analyzing the correspondence of RNA editing sites to protein three-dimensional structures.Plant & cell physiology · 2009Article
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Authors and funding
3 authors.
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Abstract
backgroundRNA editing is a type of post-transcriptional modification of RNA and belongs to the class of mechanisms that contribute to the complexity of transcriptomes. C-to-U RNA editing is commonly observed in plant mitochondria and chloroplasts. The in vivo mechanism of recognizing C-to-U RNA editing sites is still unknown. In recent years, many efforts have been made to computationally predict C-to-U RNA editing sites in the mitochondria of seed plants, but there is still no algorithm available for C-to-U RNA editing site prediction in the chloroplasts of seed plants.
resultsIn this paper, we extend our algorithm CURE, which can accurately predict the C-to-U RNA editing sites in mitochondria, to predict C-to-U RNA editing sites in the chloroplasts of seed plants. The algorithm achieves over 80% sensitivity and over 99% specificity. We implement the algorithm as an online service called CURE-Chloroplast http://bioinfo.au.tsinghua.edu.cn/pure.
conclusionCURE-Chloroplast is an online service for predicting the C-to-U RNA editing sites in the chloroplasts of seed plants. The online service allows the processing of entire chloroplast genome sequences. Since CURE-Chloroplast performs very well, it could be a helpful tool in the study of C-to-U RNA editing in the chloroplasts of seed plants.
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