ArticleScandinavian journal of medicine & science in sports2009
Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance.
Article in Scandinavian journal of medicine & science in sports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Understanding Tendons: Lessons from Transgenic Mouse Models.Stem cells and development · 2018Pooled it
- Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint.European journal of histochemistry : EJH · 2011Trial
- A novel injectable fibromodulin-releasing granular hydrogel for tendon healing and functional recovery.Bioengineering & translational medicine · 2023Article
- Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function.Matrix biology plus · 2022Article
- Hedgehog signaling underlying tendon and enthesis development and pathology.Matrix biology : journal of the International Society for Matrix Biology · 2022Review
- The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation.Frontiers in cell and developmental biology · 2021Article
- Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction.Nanoscale advances · 2020Review
- Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging.Cells · 2018Review
- The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.JCI insight · 2018Article
- Tendinopathy: injury, repair, and current exploration.Drug design, development and therapy · 2018Review
- Small leucine rich proteoglycans, a novel link to osteoclastogenesis.Scientific reports · 2017Article
- Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells.Tissue engineering. Part A · 2017Article
- Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model.Journal of biomechanics · 2015Article
- Tendon functional extracellular matrix.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Review
- Effect of interleukin-1beta and dehydroepiandrosterone on the expression of lumican and fibromodulin in fibroblast-like synovial cells of the human temporomandibular joint.European journal of histochemistry : EJH · 2015Article
- Comparative transcriptional analysis of three human ligaments with distinct biomechanical properties.Journal of anatomy · 2013Article
- The role of the non-collagenous matrix in tendon function.International journal of experimental pathology · 2013Review
- Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.Arthritis · 2013Review
- Decorin expression is important for age-related changes in tendon structure and mechanical properties.Matrix biology : journal of the International Society for Matrix Biology · 2013Article
- The biology of small leucine-rich proteoglycans in bone pathophysiology.The Journal of biological chemistry · 2012Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the Bgn KO and the most severe in the DKO. This condition progressed with age in all three mouse strains and resulted in the development of large supernumerary sesmoid bones. To determine the role of exercise in the extent of EO, we subjected normal and DKO mice to a treadmill exercise 3 days a week for 4 weeks. In contrast to previous findings using more rigorous exercise regimes, the EO in moderately exercised DKO was decreased compared with unexercised DKO mice. Finally, DKO and Bgn KO mice tested using a rotarod showed a reduced ability to maintain their grip on a rotating cylinder compared with wild-type controls. In summary, we show (1) a detailed description of EO formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.