ArticleProteins2009
Solution structure of the DNA binding domain of AraC protein.
Article in Proteins, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The CpxR-GlvR regulatory axis ofFrontiers in cellular and infection microbiology · 2026Article
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- A Twist of Fate: The Helix-Turn-Helix Motif inJournal of chemical information and modeling · 2025Article
- Phase Separation to Resolve Growth-Related Circuit Failures.bioRxiv : the preprint server for biology · 2024Article
- AraC Functional Suppressors of Mutations in the C-Terminal Domain of the RpoA Subunit of theMicroorganisms · 2024Article
- Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria.PLoS biology · 2023Article
- Article
- Optimised Heterologous Expression and Functional Analysis of theInternational journal of molecular sciences · 2021Article
- Genome-Based Drug Target Identification in Human PathogenFrontiers in genetics · 2021Article
- Arabinose Alters Both Local and Distal H-D Exchange Rates in the Escherichia coli AraC Transcriptional Regulator.Biochemistry · 2019Article
- Unraveling the role of the transcriptional regulator VirS in low pH-induced responses ofThe Journal of biological chemistry · 2019Article
- A large family of anti-activators accompanying XylS/AraC family regulatory proteins.Molecular microbiology · 2016Article
- Structural and Molecular Mechanism of CdpR Involved in Quorum-Sensing and Bacterial Virulence in Pseudomonas aeruginosa.PLoS biology · 2016Article
- Analysis of amino acid substitutions in AraC variants that respond to triacetic acid lactone.Protein science : a publication of the Protein Society · 2016Article
- Transcription factor-based biosensors enlightened by the analyte.Frontiers in microbiology · 2015Review
- Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain.Nucleic acids research · 2013Article
- A gene island with two possible configurations is involved in chromatic acclimation in marine Synechococcus.PloS one · 2013Article
- Mutational analysis of the N-terminal domain of UreR, the positive transcriptional regulator of urease gene expression.Microbiological research · 2012Article
- Computer-based annotation of putative AraC/XylS-family transcription factors of known structure but unknown function.Journal of biomedicine & biotechnology · 2012Article
- Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda.The Journal of biological chemistry · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
We report the solution structure of the DNA binding domain of the Escherichia coli regulatory protein AraC determined in the absence of DNA. The 20 lowest energy structures, determined on the basis of 1507 unambiguous nuclear Overhauser restraints and 180 angle restraints, are well resolved with a pair wise backbone root mean square deviation of 0.7 A. The protein, free of DNA, is well folded in solution and contains seven helices arranged in two semi-independent sub domains, each containing one helix-turn-helix DNA binding motif, joined by a 19 residue central helix. This solution structure is discussed in the context of extensive biochemical and physiological data on AraC and with respect to the DNA-bound structures of the MarA and Rob homologs.
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