ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2009
A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Evaluation of the Utility, Optimal Cutoff and Positive Predictive Value of a Pharyngeal Potential of Hydrogen (pH) Probe for Predicting Proton Pump Inhibitor Response in Treatment Naive Laryngopharyngeal Reflux
Effect of Extraesophageal Reflux on Inferior Nasal Turbinates Hypertrophy
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- European clinical practice guideline: managing and treating laryngopharyngeal reflux disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Guideline
- ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.The American journal of gastroenterology · 2020Guideline
- Comparison of tube feeding in stroke patients: Nasogastric tube feeding versus oroesophageal tube feeding-A pilot study.Medicine · 2019Trial
- First agreement analysis and day-to-day comparison of pharyngeal pH monitoring with pH/impedance monitoring in patients with suspected laryngopharyngeal reflux.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Trial
- Article
- Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review.Journal of personalized medicine · 2023Review
- Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified?BMC gastroenterology · 2023Review
- Gastroesophageal reflux disease in children: What's new right now?World journal of gastrointestinal endoscopy · 2023Review
- High incidence of dyspnoea and pulmonary aspiration in giant hiatus hernia: a previously unrecognised cause of dyspnoea.Annals of the Royal College of Surgeons of England · 2022Article
- Utility of reflux finding score and reflux symptom index in diagnosis of laryngopharyngeal reflux disease.Laryngoscope investigative otolaryngology · 2022Article
- Clinical Update Findings about pH-Impedance Monitoring Features in Laryngopharyngeal Reflux Patients.Journal of clinical medicine · 2022Review
- A simple qualitative scale for diagnosis of laryngopharyngeal reflux: high correlations with pH measurements and disease severity. The usefulness of the Warsaw Scale in LPR diagnostics compared to other diagnostic tools.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Laryngopharyngeal Reflux Among Patients Undergoing Bariatric Surgery.Obesity surgery · 2021Article
- [Value of airway pH monitoring in determining the association between chronic cough and laryngopharyngeal reflux in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Gastrointestinal function testing model using a new laryngopharyngeal pH probe (Restech) in patients after Ivor-Lewis esophagectomy.World journal of gastrointestinal oncology · 2021Article
- Evaluation of Oropharyngeal pH-Monitoring in the Assessment of Laryngopharyngeal Reflux.Journal of clinical medicine · 2021Article
- Laryngopharyngeal pH Monitoring in Patients With Idiopathic Pulmonary Fibrosis.Frontiers in pharmacology · 2021Article
- [Analysis of the effect of noninvasive positive-pressure ventilation with simultaneous detection of Dx-pH monitoring in oropharynx and esophagus for 48 hours in patients with moderate and severe OSA].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study.Respiratory research · 2020Article
- Pepsin and oropharyngeal pH monitoring to diagnose patients with laryngopharyngeal reflux.The Laryngoscope · 2020Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIdentifying gastroesophageal reflux disease as the cause of respiratory and laryngeal complaints is difficult and depends largely on the measurements of increased acid exposure in the upper esophagus or ideally the pharynx. The current method of measuring pharyngeal pH environment is inaccurate and problematic due to artifacts. A newly designed pharyngeal pH probe to avoid these artifacts has been introduced. The aim of this study was to use this probe to measure the pharyngeal pH environment in normal subjects and establish pH thresholds to identify abnormality.
methodsAsymptomatic volunteers were studied to define the normal pharyngeal pH environment. All subjects underwent esophagram, esophageal manometry, upper and lower esophageal pH monitoring with a dual-channel pH catheter and pharyngeal pH monitoring with the new probe. Analyses were performed at 0.5 pH intervals between pH 4 and 6.5 to identify the best discriminating pH threshold and calculate a composite pH score to identify an abnormal pH environment.
resultsThe study population consisted of 55 normal subjects. The pattern of pharyngeal pH environment was significantly different in the upright and supine periods and required different thresholds. The calculated discriminatory pH threshold was 5.5 for upright and 5.0 for supine periods. The 95th percentile values for the composite score were 9.4 for upright and 6.8 for supine.
conclusionA new pharyngeal pH probe which detects aerosolized and liquid acid overcomes the artifacts that occur in measuring pharyngeal pH with existing catheters. Discriminating pH thresholds were selected and normal values defined to identify patients with an abnormal pharyngeal pH environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.