SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009
Excess mortality following hip fracture: a systematic epidemiological review.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 486 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Evaluation of the Safety of a Local Osteo-Enhancement Procedure (LOEP™) Intended to Increase Bone Strength in the Proximal Femur of Women in Europe With Osteoporosis
Cognitive Changes After Hip Prosthesis; Comparison Between Combined Lumbosacral Nerve Block Versus Spinal Anesthesia: A Double Blind Randomized Clinical Trial
Who cites it
486 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,042 citations in OpenAlex.
- Mortality in patients over 65 with proximal humerus fractures: a systematic review of 414,379 shoulders with meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Neutrophil-to-lymphocyte ratio for predicting postoperative mortality after hip fracture surgery: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- The Association between Red Blood Cell Distribution Width and Mortality Risk after Hip Fracture: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Correlation between C-reactive protein and postoperative mortality in patients undergoing hip fracture surgery: a meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Synthesis of the evidence on the impact of pre-operative direct oral anticoagulants on patient health outcomes after hip fracture surgery: rapid systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Pooled it
- Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis.Calcified tissue international · 2022Pooled it
- Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis: A Meta-analysis of Randomized Clinical Trials.JAMA internal medicine · 2022Pooled it
- The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis.Aging clinical and experimental research · 2021Pooled it
- Association of depressive disorders and dementia with mortality among older people with hip fracture.BMC geriatrics · 2023Trial
- Trial
- Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review).Molecular medicine reports · 2026Review
- Article
- Aggregation-Sensitive Mortality Associations and Firth Penalized Logistic Regression After Hip Fracture Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- When demography challenges policy: the rising burden of proximal femur fractures as a role model and driver for geriatric trauma care in Germany.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Time to surgery and its impact on length of stay and mortality for neck of femur fractures at a major trauma centre.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Association Between Immediate Postoperative Pulse Pressure and Three-Year All-Cause Mortality After Hip Fracture Surgery in Older Adults: A Post Hoc Analysis of a Prospective Cohort.Journal of clinical medicine · 2026Article
- Predictive value of MON/HDL ratio on mortality at 1 and 6 months in patients over 65 years of age scheduled for hip fracture surgery.Medicine · 2026Article
- Serial Presepsin Measurement as a Predictor of In-Hospital Mortality in Older Adults with Hip Fractures.Life (Basel, Switzerland) · 2026Article
- Investigating the association between angina and osteoporosis: a 20-year longitudinal cohort study of ELSA.BMC public health · 2026Article
- The Surgical Timing Gap in Elderly Hip Fracture Management: A Regional Systems Analysis.Cureus · 2026Article
426 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 5 countries.
Funding
Abstract
This systematic literature review has shown that patients experiencing hip fracture after low-impact trauma are at considerable excess risk for death compared with nonhip fracture/community control populations. The increased mortality risk may persist for several years thereafter, highlighting the need for interventions to reduce this risk.Patients experiencing hip fracture after low-impact trauma are at considerable risk for subsequent osteoporotic fractures and premature death. We conducted a systematic review of the literature to identify all studies that reported unadjusted and excess mortality rates for hip fracture. Although a lack of consistent study design precluded any formal meta-analysis or pooled analysis of the data, we have shown that hip fracture is associated with excess mortality (over and above mortality rates in nonhip fracture/community control populations) during the first year after fracture ranging from 8.4% to 36%. In the identified studies, individuals experienced an increased relative risk for mortality following hip fracture that was at least double that for the age-matched control population, became less pronounced with advancing age, was higher among men than women regardless of age, was highest in the days and weeks following the index fracture, and remained elevated for months and perhaps even years following the index fracture. These observations show that patients are at increased risk for premature death for many years after a fragility-related hip fracture and highlight the need to identify those patients who are candidates for interventions to reduce their risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.