ArticleInternational journal of nanomedicine2009
Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells.
Article in International journal of nanomedicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Nanoparticles for hematologic diseases detection and treatment.Hematology & medical oncology · 2019Article
- Article
- Preparation, Optimization and Toxicity Evaluation of (SPION-PLGA) ±PEG Nanoparticles Loaded with Gemcitabine as a Multifunctional Nanoparticle for Therapeutic and Diagnostic Applications.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin.Drug design, development and therapy · 2015Article
- Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced Apoptosis.Biomaterials science · 2014Article
- Tumor targeting using magnetic nanoparticle Hsp70 conjugate in a model of C6 glioma.Neuro-oncology · 2014Article
- Anthracycline Nano-Delivery Systems to Overcome Multiple Drug Resistance: A Comprehensive Review.Nano today · 2013Article
- Investigation of the Effect of Folic Acid Based Iron Oxide Nanoparticles on Human Leukemic CCRF-CEM Cell Line.Iranian journal of pediatric hematology and oncology · 2013Article
- Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance.International journal of nanomedicine · 2012Article
- Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery.International journal of nanomedicine · 2012Article
- Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic iron oxide nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin.International journal of nanomedicine · 2011Article
- Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles.International journal of nanomedicine · 2011Article
- The changes of T lymphocytes and cytokines in ICR mice fed with Fe3O4 magnetic nanoparticles.International journal of nanomedicine · 2011Article
- Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies.International journal of nanomedicine · 2010Article
- Magnetic Fe₃O₄ nanoparticles and chemotherapy agents interact synergistically to induce apoptosis in lymphoma cells.International journal of nanomedicine · 2010Article
- Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice.International journal of nanomedicine · 2010Article
- Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells.International journal of nanomedicine · 2009Article
- Inorganic Nanoparticles as Drug Delivery Systems and Their Potential Role in the Treatment of Chronic Myelogenous Leukaemia.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe(3)O(4)) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe(3)O(4)) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML.
Indexed as
Identifiers
19421371PMC2720739W1968150155What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.