ArticlePloS one2009
MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
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- The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy.Cell communication and signaling : CCS · 2024Article
- Metronomic and single high-dose paclitaxel treatments produce distinct heterogenous chemoresistant cancer cell populations.Scientific reports · 2023Article
- The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells.Pharmaceutics · 2023Article
- Article
- Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring.International journal of molecular sciences · 2022Review
- Polyploidy in development and tumor models in Drosophila.Seminars in cancer biology · 2022Review
- MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment.International journal of molecular sciences · 2021Review
- UNR/Journal of clinical medicine · 2019Article
- Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells.Oncology letters · 2018Article
- Myc regulates programmed cell death and radial glia dedifferentiation after neural injury in an echinoderm.BMC developmental biology · 2015Article
- Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells.Journal of translational medicine · 2014Article
- MYCN gene expression is required for the onset of the differentiation programme in neuroblastoma cells.Cell death & disease · 2014Article
- Inference of radio-responsive gene regulatory networks using the graphical lasso algorithm.BMC bioinformatics · 2014Article
- Classic "broken cell" techniques and newer live cell methods for cell cycle assessment.American journal of physiology. Cell physiology · 2013Review
- A statin-regulated microRNA represses human c-Myc expression and function.EMBO molecular medicine · 2012Article
- Regulation of embryonic stem cell pluripotency by heat shock protein 90.Stem cells (Dayton, Ohio) · 2012Article
- Metabolic restriction of cancer cells in vitro causes karyotype contraction--an indicator of cancer promotion?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cells: comparison to peloruside A.Investigational new drugs · 2012Article
- Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells.Investigational new drugs · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the MYC oncogene in the apoptotic pathways is not fully understood. MYC has been reported to protect cells from apoptosis activation but also to sensitize cells to apoptotic stimuli. We have previously demonstrated that the down-regulation of Myc protein activates apoptosis in melanoma cells and increases the susceptibility of cells to various antitumoral treatments. Beyond the well-known role in the G1-->S transition, MYC is also involved in the G2-M cell cycle phases regulation. METHODOLOGY/PRINCIPAL
findingsIn this study we have investigated how MYC could influence cell survival signalling during G2 and M phases. We used the microtubules damaging agent paclitaxel (PTX), to arrest the cells in the M phase, in a p53 mutated melanoma cell line with modulated Myc level and activity. An overexpression of Myc protein is able to increase endoreduplication favoring the survival of cells exposed to antimitotic poisoning. The PTX-induced endoreduplication is associated in Myc overexpressing cells with a reduced expression of MAD2, essential component of the molecular core of the spindle assembly checkpoint (SAC), indicating an impairment of this checkpoint. In addition, for the first time we have localized Myc protein at the spindle poles (centrosomes) during pro-metaphase in different cell lines.
conclusionsThe presence of Myc at the poles during the prometaphase could be necessary for the Myc-mediated attenuation of the SAC and the subsequent induction of endoreduplication. In addition, our data strongly suggest that the use of taxane in antitumor therapeutic strategies should be rationally based on the molecular profile of the individual tumor by specifically analyzing Myc expression levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.