ArticleGenes and immunity2009
Multiple sclerosis associates with LILRA3 deletion in Spanish patients.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.PloS one · 2015Pooled it
- Human leukocyte immunoglobulin-like receptors in health and disease.Frontiers in immunology · 2023Review
- A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis.Scientific reports · 2021Article
- Leukocyte Immunoglobulin-Like Receptor A3 (LILRA3): A Novel Marker for Lymphoma Development among Patients with Young Onset Sjogren's Syndrome.Journal of clinical medicine · 2021Article
- Leukocyte immunoglobulin-like receptor A3 is increased in IBD patients and functions as an anti-inflammatory modulator.Clinical and experimental immunology · 2021Article
- LILRA3 is related to monocyte-derived dendritic cell maturation and activation.Iranian journal of basic medical sciences · 2021Article
- The Genomic Organization of theFrontiers in immunology · 2021Review
- The expression and clinical significance of different forms of LILRA3 in systemic lupus erythematosus.Clinical rheumatology · 2019Article
- Frequencies of theFrontiers in genetics · 2019Article
- [Expression of leukocyte immunoglobulin-like receptor A3 in CD14Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Article
- Atlas of human diseases influenced by genetic variants with extreme allele frequency differences.Human genetics · 2017Article
- TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads.Retrovirology · 2016Article
- Leukocyte Ig-Like Receptors - A Model for MHC Class I Disease Associations.Frontiers in immunology · 2016Review
- Article
- Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations.Journal of human genetics · 2015Review
- Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors.Immunogenetics · 2014Article
- Termination of immune activation: an essential component of healthy host immune responses.Journal of innate immunity · 2014Review
- Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein.The Journal of biological chemistry · 2013Article
- Natural killer cells and their receptors in multiple sclerosis.Brain : a journal of neurology · 2013Review
- DNA methylation as clinically useful biomarkers-light at the end of the tunnel.Pharmaceuticals (Basel, Switzerland) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic susceptibility to multiple sclerosis (MS) is only partially explained, and it shows geographic variations. We analyse here two series of Spanish patients and healthy controls and show that relapsing MS (R-MS) is associated with a gene deletion affecting the hypothetically soluble leukocyte immunoglobulin (Ig)-like receptor A3 (LILRA3, 19q13.4), in agreement with an earlier finding in German patients. Our study points to a gene-dose-dependent, protective role for LILRA3, the deletion of which synergizes with HLA-DRB1(*)1501 to increase the risk of R-MS. We also investigated whether the risk of suffering R-MS might be influenced by the genotypic diversity of killer-cell Ig-like receptors (KIRs), located only approximately 400 kb telomeric to LILRA3, and implicated in autoimmunity and defence against viruses. The relationship of LILRA3 deletion with R-MS is not secondary to linkage disequilibrium with a KIR gene, but we cannot exclude some contributions of KIR to the genetic susceptibility to R-MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.