ArticleBlood2009
C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration.BMC developmental biology · 2011Pooled it
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- Prdx6 regulatesAnimal cells and systems · 2025Article
- Association of the invasiveness of colon cancer with the expression of C/EBPα.Oncology letters · 2019Article
- The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies inRegeneration (Oxford, England) · 2016Article
- Identification of genes expressed in the migrating primitive myeloid lineage of Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Xenopus: An in vivo model for imaging the inflammatory response following injury and bacterial infection.Developmental biology · 2015Article
- NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Expression and localization of Rdd proteins in Xenopus embryo.Anatomy & cell biology · 2014Article
- Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks.Cellular and molecular life sciences : CMLS · 2014Review
- Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin.PloS one · 2013Article
- Review
- The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st century.Developmental and comparative immunology · 2011Review
- Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo.Development (Cambridge, England) · 2010Article
- FGF signalling: diverse roles during early vertebrate embryogenesis.Development (Cambridge, England) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The molecular mechanisms that underlie the development of primitive myeloid cells in vertebrate embryos are not well understood. Here we characterize the role of cebpa during primitive myeloid cell development in Xenopus. We show that cebpa is one of the first known hematopoietic genes expressed in the embryo. Loss- and gain-of-function studies show that it is both necessary and sufficient for the development of functional myeloid cells. In addition, we show that cebpa misexpression leads to the precocious induction of myeloid cell markers in pluripotent prospective ectodermal cells, without the cells transitioning through a general mesodermal state. Finally, we use live imaging to show that cebpa-expressing cells exhibit many attributes of terminally differentiated myeloid cells, such as highly active migratory behavior, the ability to quickly and efficiently migrate toward wounds and phagocytose bacteria, and the ability to enter the circulation. Thus, C/EPBalpha is the first known single factor capable of initiating an entire myelopoiesis pathway in pluripotent cells in the embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.