ArticleInvestigative ophthalmology & visual science2009
Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.Human genetics · 2015Pooled it
- Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.PLoS genetics · 2011Pooled it
- Estimating the relationship between fitness and metabolic rate: which rate should we use?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- 10 Years of GWAS in intraocular pressure.Frontiers in genetics · 2023Review
- Genome-wide association study finds multiple loci associated with intraocular pressure in HS rats.Frontiers in genetics · 2022Article
- Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia.Investigative ophthalmology & visual science · 2021Article
- Genomic Locus Modulating IOP in the BXD RI Mouse Strains.G3 (Bethesda, Md.) · 2018Article
- A survey on computer aided diagnosis for ocular diseases.BMC medical informatics and decision making · 2014Review
- Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma.Frontiers in molecular neuroscience · 2014Review
- Coordinated genetic scaling of the human eye: shared determination of axial eye length and corneal curvature.Investigative ophthalmology & visual science · 2013Article
- A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.Molecular vision · 2013Article
- The intraocular pressure response to dehydration: a pilot study.European journal of applied physiology · 2012Article
- Ophthalmic phenotypes and the representativeness of twin data for the general population.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo analyze the effect of using one reading, the mean of two readings (from the same eye), or the mean of four readings (two from each eye) on the heritability estimates of intraocular pressure (IOP). This was a cohort study in which 344 pairs of twins, 163 monozygotic (MZ) and 181 dizygotic (DZ), were enrolled.
methodsIOP was measured using three tonometers: the gold standard Goldmann applanation tonometer (GAT), the Ocular Response Analyzer (ORA; Reichert Buffalo, NY), and the Dynamic Contour Tonometer (DCT, Pascal; Swiss Microtechnology AG, Port, Switzerland). The main outcome measure was the heritability of IOP correlated with the number of measurements.
resultsThe mean IOPs of all four readings with the three tonometers were: 14.1 +/- 2.9 mm Hg for GAT, 15.9 +/- 3.2 mm Hg for ORA, and 16.9 +/- 2.7 mm Hg for DCT. As the number of readings increased, the calculated heritability (h(2)) of IOP measured using the GAT readings increased from 0.56 for one reading (95% confidence interval [CI], 0.44-0.65) to 0.58 for the mean of two readings (95% CI, 0.46-0.67) to 0.64 for the mean of all four readings (two right and two left; 95% CI, 0.55-0.72). Similar results were seen with the other two instruments.
conclusionsThe results demonstrated that the use of the mean of several readings from both eyes reduced measurement error, yielding a higher heritability estimate. The higher heritability would increase the power to detect linkage in a genome-wide analysis.
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