ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 72 citations in OpenAlex.
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- Ageing as a two-phase process: theoretical framework.Frontiers in aging · 2024Article
- Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature.Aging cell · 2023Article
- Markers and mechanisms of death inFrontiers in aging · 2023Article
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- Role of heat shock proteins in aging and chronic inflammatory diseases.GeroScience · 2021Review
- Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.PLoS genetics · 2021Article
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- Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis.Frontiers in physiology · 2020Review
- Analysis of Drosophila melanogaster Lifespan.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins.Nature communications · 2019Article
- Expression of Heat Shock Protein 70 Is Insufficient To ExtendG3 (Bethesda, Md.) · 2019Article
- Behavioral and molecular markers of death in Drosophila melanogaster.Experimental gerontology · 2019Article
- Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- The role of declining adaptive homeostasis in ageing.The Journal of physiology · 2017Review
- Small heat shock proteins in ageing and age-related diseases.Cell stress & chaperones · 2017Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila Hsp70 is a highly conserved molecular chaperone with numerous cytoplasmic targets. Hsp22 is an alpha-crystallin-related chaperone (small hsp) that localizes to the mitochondrial matrix. The hsp70 and hsp22 genes are induced in response to acute heat and oxidative stress and are also upregulated during normal aging. Here the hsp22 promoter (-314 to +10) and the hsp70 promoter (-194 to +10) were used to drive expression of the fluorescent reporter proteins green fluorescent protein (GFP) and Discosoma sp. red fluorescent protein (DsRED) in transgenic flies. Multiple transgenic lines were analyzed under normal culture conditions and under oxidative stress and heat stress conditions that significantly shorten life span. Flies were individually housed, and GFP (or DsRED) was quantified at young-age time points using the fluorescence stereomicroscope and image analysis software. Expression of the hsp reporters in young flies was partially predictive of remaining life span: Young flies with high expression tended to die sooner under both control and stress conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.