ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
A genetically mediated bias in decision making driven by failure of amygdala control.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions.Brain structure & function · 2017Pooled it
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals.PLoS biology · 2017Trial
- Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study.Genes, brain, and behavior · 2012Trial
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Guilt emotion and decision-making under uncertainty.Frontiers in psychology · 2025Article
- A systematic review of risky-choice framing effects.EXCLI journal · 2023Review
- Domain-specific neural substrates underlie the framing effect.Neuroimage. Reports · 2022Article
- Neuroanatomical Correlates of Mild-to-Moderate Depression: Memory Ability Mediates the Association Between Gray Matter Volume and Antidepressant Treatment Outcome.Frontiers in neuroscience · 2022Article
- Prosocial Gains and Losses: Modulations of Human Social Decision-Making by Loss-Gain Context.Frontiers in psychology · 2021Article
- Retrospective Valuation of Experienced Outcome Encoded in Distinct Reward Representations in the Anterior Insula and Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.NeuroImage · 2020Article
- The Neural Mechanism of the Social Framing Effect: Evidence from fMRI and tDCS Studies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains".Frontiers in neuroscience · 2020Article
- Trait and State-Dependent Risk Attitude of Monkeys Measured in a Single-Option Response Task.Frontiers in neuroscience · 2019Article
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- Behavioral preference in sequential decision-making and its association with anxiety.Human brain mapping · 2018Article
- Network approach for decision making under risk-How do we choose among probabilistic options with the same expected value?PloS one · 2018Article
- Neural underpinnings of maladaptive decision-making in addictions.Pharmacology, biochemistry, and behavior · 2018Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic variation at the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with altered amygdala reactivity and lack of prefrontal regulatory control. Similar regions mediate decision-making biases driven by contextual cues and ambiguity, for example the "framing effect." We hypothesized that individuals hemozygous for the short (s) allele at the 5-HTTLPR would be more susceptible to framing. Participants, selected as homozygous for either the long (la) or s allele, performed a decision-making task where they made choices between receiving an amount of money for certain and taking a gamble. A strong bias was evident toward choosing the certain option when the option was phrased in terms of gains and toward gambling when the decision was phrased in terms of losses (the frame effect). Critically, this bias was significantly greater in the ss group compared with the lala group. In simultaneously acquired functional magnetic resonance imaging data, the ss group showed greater amygdala during choices made in accord, compared with those made counter to the frame, an effect not seen in the lala group. These differences were also mirrored by differences in anterior cingulate-amygdala coupling between the genotype groups during decision making. Specifically, lala participants showed increased coupling during choices made counter to, relative to those made in accord with, the frame, with no such effect evident in ss participants. These data suggest that genetically mediated differences in prefrontal-amygdala interactions underpin interindividual differences in economic decision making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.