ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Genome Integrity and Neurological Disease.International journal of molecular sciences · 2022Review
- Parallel mechanisms of visual memory formation across distinct regions of the honey bee brain.The Journal of experimental biology · 2021Article
- Identification and Characterization of the V(D)J Recombination Activating Gene 1 in Long-Term Memory of Context Fear Conditioning.Neural plasticity · 2016Article
- Epigenetic mechanisms in learned fear: implications for PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation.PloS one · 2013Article
- Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?NPJ science of learningArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
We previously proposed that DNA recombination/repair processes play a role in memory formation. Here, we examined the possible role of the fen-1 gene, encoding a flap structure-specific endonuclease, in memory consolidation of conditioned taste aversion (CTA). Quantitative real-time PCR showed that amygdalar fen-1 mRNA induction was associated to the central processing of the illness experience related to CTA and to CTA itself, but not to the central processing resulting from the presentation of a novel flavor. CTA also increased expression of the Fen-1 protein in the amygdala, but not the insular cortex. In addition, double immunofluorescence analyses showed that amygdalar Fen-1 expression is mostly localized within neurons. Importantly, functional studies demonstrated that amygdalar antisense knockdown of fen-1 expression impaired consolidation, but not short-term memory, of CTA. Overall, these studies define the fen-1 endonuclease as a new DNA recombination/repair factor involved in the formation of long-term memories.
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Registered trials
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