ArticleProceedings of the National Academy of Sciences of the United States of America2009
Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Induction of excitatory brain state governs plastic functional changes in visual cortical topology.Brain structure & function · 2024Review
- NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush.International journal of molecular sciences · 2021Article
- Mesoscopic cortical network reorganization during recovery of optic nerve injury in GCaMP6s mice.Scientific reports · 2020Article
- Rapid topographic reorganization in adult human primary visual cortex (V1) during noninvasive and reversible deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Altered Sensitivity to Motion of Area MT Neurons Following Long-Term V1 Lesions.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- High-resolution VSDI retinotopic mapping via a DLP-based projection system.Biomedical optics express · 2019Article
- Axonal plasticity associated with perceptual learning in adult macaque primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Catching the voltage gradient-asymmetric boost of cortical spread generates motion signals across visual cortex: a brief review with special thanks to Amiram Grinvald.Neurophotonics · 2017Review
- Seeing the sound after visual loss: functional MRI in acquired auditory-visual synesthesia.Experimental brain research · 2017Article
- Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats.Neural plasticity · 2017Article
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- Developmental Sculpting of Intracortical Circuits by MHC Class I H2-Db and H2-Kb.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Temporal Asymmetry in Dark-Bright Processing Initiates Propagating Activity across Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Large-scale axonal reorganization of inhibitory neurons following retinal lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A simple rule for dendritic spine and axonal bouton formation can account for cortical reorganization after focal retinal lesions.PLoS computational biology · 2013Article
- The second face of blindness: processing speed deficits in the intact visual field after pre- and post-chiasmatic lesions.PloS one · 2013Article
- The role of inhibition in oscillatory wave dynamics in the cortex.The European journal of neuroscience · 2012Article
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3 authors.
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Abstract
Sensory deprivation caused by peripheral injury can trigger functional cortical reorganization across the initially silenced cortical area. It is proposed that intracortical connectivity enables recovery of function within such a lesion projection zone (LPZ), thus substituting lost subcortical input. Here, we investigated retinal lesion-induced changes in the function of lateral connections in the primary visual cortex of the adult rat. Using voltage-sensitive dye recordings, we visualized in millisecond-time resolution spreading synaptic activity across the LPZ. Shortly after lesion, the majority of neurons within the LPZ were subthresholdly activated by delayed propagation of activity that originated from unaffected cortical regions. With longer recovery time, latencies within the LPZ gradually decreased, and activation reached suprathreshold levels. Targeted electrode recordings confirmed that receptive fields of intra-LPZ neurons were displaced to the retinal lesion border while displaying normal orientation and direction selectivity. These results corroborate the view that cortical horizontal connections have a central role in functional reorganization, as revealed here by progressive facilitation of synaptic activity and the traveling wave of excitation that propagates horizontally into the deprived cortical region.
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