ArticleJournal of clinical microbiology2009
Occurrence, population structure, and antimicrobial resistance of enterococci in marginal and apical periodontitis.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Global Prevalence of Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis Isolated From Clinical and Environmental Sources: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
- Diversity of Endodontic Enterococcus faecalis from Brazil with a High Occurrence of the ST 397 Clone.Brazilian dental journal · 2024Article
- Microbial Communities in the Extraradicular and Intraradicular Infections Associated With Persistent Apical Periodontitis.Frontiers in cellular and infection microbiology · 2021Article
- Improving the Efficiency of Photodynamic Chemotherapy in Root Canals againstAntibiotics (Basel, Switzerland) · 2020Article
- Assessment of Nitrofurantoin as an Experimental Intracanal Medicament in Endodontics.BioMed research international · 2020Article
- The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers.BMC oral health · 2018Article
- Evaluation of the Effect of MTAD on Expression of Enterococcus faecalis Virulence Factors Considering the Role of Different Obturating Materials.Journal of dentistry (Tehran, Iran) · 2018Article
- Comparative genomics of Enterococcus spp. isolated from bovine feces.BMC microbiology · 2017Article
- Biofilm Formation by Drug Resistant Enterococci Isolates Obtained from Chronic Periodontitis Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
- Effects of Diode Laser, Gaseous Ozone, and Medical Dressings onBioMed research international · 2017Article
- Transcription factor Rex in regulation of pathophysiology in oral pathogens.Molecular oral microbiology · 2016Review
- Effect of photodynamic therapy (PDT) on Enterococcus faecalis biofilm in experimental primary and secondary endodontic infections.BMC oral health · 2014Article
- Single consumption of Bryndza cheese temporarily affects oral microbiota and salivary markers of oxidative stress.Current microbiology · 2014Article
- Characterisation of the plasmidome within Enterococcus faecalis isolated from marginal periodontitis patients in Norway.PloS one · 2013Article
- Enterococcus faecalis affects the proliferation and differentiation of ovine osteoblast-like cells.Clinical oral investigations · 2012Article
- Enterococcus faecalis from patients with chronic periodontitis: virulence and antimicrobial resistance traits and determinants.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections.Journal of oral microbiology · 2012Article
- Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.FEMS microbiology reviews · 2011Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subgingival plaque samples and root canal samples were collected from 2,839 marginal periodontitis (MP) patients and 21 apical periodontitis (AP) patients. Enterococcus species were identified by a series of phenotypic and genotypic tests. Antimicrobial susceptibility assays were performed by an agar disk diffusion test. Multilocus sequence typing (MLST), eBURST, and minimum spanning tree were used for enterococcal genetic clustering and population analysis. Enterococcus faecalis was recovered from 3.7% MP patients and 9.5% AP patients, and Enterococcus faecium was recovered from 0.04% MP patients. Enterococci were detected more often in older male patients. E. faecalis isolates of MP were found resistant to tetracycline (49.1%), erythromycin (8.5%), trimethoprim (2.8%), and gentamicin (1.9%), while one AP isolate was resistant to tetracycline. A total of 40 sequence types (STs) were resolved in 108 E. faecalis isolates. Comparison with E. faecalis international MLST database revealed that 27 STs were previously found, 13 STs were novel, and several major clonal complexes in the database were also found in MP isolates. The tetracycline-resistant isolates distributed mainly in the major clonal complexes and singletons, whereas the erythromycin-resistant isolates were more dispersed. Although the rate of occurrence of enterococci recovered in the MP and AP samples was low, 50% of these isolates are resistant to at least one antimicrobial agent, which is most often tetracycline. This implies that subgingival E. faecalis might represent a reservoir of resistance to tetracycline and erythromycin. The subgingival E. faecalis isolates show high genetic diversity but are grouped, in general, with the known isolates from the international database.
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