ArticleAmerican journal of physiology. Renal physiology2009
Novel use of ultrasound to examine regional blood flow in the mouse kidney.
Article in American journal of physiology. Renal physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Contrast-Enhanced Ultrasound Reveals Partial Perfusion Recovery After Hindlimb Ischemia as Opposed to Full Recovery by Laser Doppler Perfusion Imaging.Ultrasound in medicine & biology · 2022Article
- Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study.BMC nephrology · 2018Observational
- Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats.Clinical science (London, England : 1979) · 2018Article
- Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease.European journal of pharmacology · 2016Review
- Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis.Immunology · 2016Article
- Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats.Journal of visualized experiments : JoVE · 2016Article
- Contrast-Based Real-Time Assessment of Microcirculatory Changes in a Fatty Liver After Ischemia Reperfusion Injury.Journal of pediatric gastroenterology and nutrition · 2016Article
- The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.Scientific reports · 2016Article
- Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.American journal of physiology. Renal physiology · 2015Article
- Renal effects of treatment with a TLR4 inhibitor in conscious septic sheep.Critical care (London, England) · 2014Article
- Renal blood flow and oxygenation drive nephron progenitor differentiation.American journal of physiology. Renal physiology · 2014Article
- Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging.American journal of physiology. Renal physiology · 2013Article
- Polycystic kidneys have decreased vascular density: a micro-CT study.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Quantitative evaluation of contrast-enhanced ultrasonography in the diagnosis of chronic ischemic renal disease in a dog model.PloS one · 2013Article
- Use of ultrasound to assess renal reperfusion and P-selectin expression following unilateral renal ischemia.American journal of physiology. Renal physiology · 2012Article
- Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.Pharmacology & therapeutics · 2012Review
- The effect of inhaled gases on ultrasound contrast agent longevity in vivo.Molecular imaging and biology · 2012Article
- Monitoring antivascular therapy in head and neck cancer xenografts using contrast-enhanced MR and US imaging.Angiogenesis · 2011Article
- Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Doppler velocity measurements from large and small arteries of mice.American journal of physiology. Heart and circulatory physiology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Conventional methods used for measuring regional renal blood flow, such as laser-Doppler flowmetry, are highly invasive, and each measurement is restricted to a discrete location. The aim of this study was to determine whether ultrasound imaging in conjunction with enhanced contrast agent (microbubbles; Vevo MicroMarker, VisualSonics) could provide a viable noninvasive alternative. This was achieved by determining changes in renal cortical and medullary rate of perfusion in response to a bolus injection of endothelin-1 (ET-1; 0.6, 1.0, or 2.0 nmol/kg) and comparing these responses to those observed in separate groups of mice with conventional laser-Doppler methods. Intravenous infusion of ET-1 in anesthetized male C57bl/6 mice resulted in a dose-dependent increase in mean arterial pressure and a dose-dependent decrease in total renal blood flow as measured by pulse-wave Doppler. ET-1 infusion resulted in a dose-dependent decrease in regional kidney perfusion as measured by both ultrasound with enhanced contrast agent and laser-Doppler measurements, verifying the use of ultrasound to measure regional kidney perfusion. Noted limitations of ultrasound imaging compared with laser-Doppler flowmetry included a lower degree of sensitivity to changes in tissue perfusion and the inability to assess rapid or transient changes in tissue perfusion. In conclusion, ultrasound represents an effective and noninvasive method for the measurement of relatively short-term, steady-state changes in regional blood flow in the mouse kidney.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.