ArticleNucleic acids research2009
OptiTope--a web server for the selection of an optimal set of peptides for epitope-based vaccines.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- PepLess: A computational tool developed to optimize SPOT synthesis and analyze related immunoassay data.Biochemistry and biophysics reports · 2025Article
- Quantification of heterogeneity in human CD8Frontiers in immunology · 2024Article
- Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus.Nano research · 2023Article
- Exploring the COVID-19 vaccine candidates against SARS-CoV-2 and its variants: where do we stand and where do we go?Human vaccines & immunotherapeutics · 2021Review
- PopCover-2.0. Improved Selection of Peptide Sets With Optimal HLA and Pathogen Diversity Coverage.Frontiers in immunology · 2021Article
- A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach.Frontiers in immunology · 2021Article
- ImmunoNodes - graphical development of complex immunoinformatics workflows.BMC bioinformatics · 2017Article
- FRED 2: an immunoinformatics framework for Python.Bioinformatics (Oxford, England) · 2016Article
- Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production.Human vaccines & immunotherapeutics · 2016Article
- Designing string-of-beads vaccines with optimal spacers.Genome medicine · 2016Article
- Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach.Journal of tropical medicine · 2015Article
- Designing peptide-based HIV vaccine for Chinese.BioMed research international · 2014Article
- Article
- Immune epitope database analysis resource.Nucleic acids research · 2012Article
- Systems biology in vaccine design.Microbial biotechnology · 2012Review
- Vaccines: from empirical development to rational design.PLoS pathogens · 2012Review
- Virtual interactomics of proteins from biochemical standpoint.Molecular biology international · 2012Article
- Characterization of HIV-specific CD4+ T cell responses against peptides selected with broad population and pathogen coverage.PloS one · 2012Article
- POPISK: T-cell reactivity prediction using support vector machines and string kernels.BMC bioinformatics · 2011Article
- State of the art and challenges in sequence based T-cell epitope prediction.Immunome research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epitope-based vaccines (EVs) have recently been attracting significant interest. They trigger an immune response by confronting the immune system with immunogenic peptides derived from, e.g. viral- or cancer-related proteins. Binding of these peptides to proteins from the major histocompatibility complex (MHC) is crucial for immune system activation. However, since the MHC is highly polymorphic, different patients typically bind different repertoires of peptides. Furthermore, economical and regulatory issues impose strong limitations on the number of peptides that can be included in an EV. Hence, it is crucial to identify the optimal set of peptides for a vaccine, given constraints such as MHC allele probabilities in the target population, peptide mutation rates and maximum number of selected peptides. OptiTope aims at assisting immunologists in this critical task. With OptiTope, we provide an easy-to-use tool to determine a provably optimal set of epitopes with respect to overall immunogenicity in a specific individual (personalized medicine) or a target population (e.g. a certain ethnic group). OptiTope is available at http://www.epitoolkit.org/optitope.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.