ArticleGynecologic oncology2009
Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
Article in Gynecologic oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Review
- Penalized logistic regression based on L1/2 penalty for high-dimensional DNA methylation data.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020Article
- Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.Molecular biology reports · 2019Article
- Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs.PloS one · 2015Article
- Global ovarian cancer health disparities.Gynecologic oncology · 2013Review
- Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis.PloS one · 2013Article
- TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.Neoplasia (New York, N.Y.) · 2010Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveWe have previously shown that TCEAL7 (transcription elongation factor A (SII)-like 7) is epigenetically down-regulated in the majority of epithelial ovarian cancers. We now examine the hypothesis that inherited alterations in TCEAL7 play a role in the etiology of ovarian cancer.
methodsA two-site case-control study of 930 cases of ovarian cancer and 1037 controls, frequency-matched on residence, age and race, was conducted. Six informative SNPs (tagSNPs and putative-functional SNPs) were genotyped. Logistic regression was used to adjust for potential confounders and determine if inherited variation at this locus was associated with risk of ovarian cancer in general and among cases with invasive disease and serous histology. Gene-level principal component and haplotype analyses were also conducted.
resultsNone of the SNPs or haplotypes studied were significantly associated with ovarian cancer risk overall. However, among the 440 invasive serous cases, the minor alleles for three correlated SNPs were significantly associated with reduced risk (p-values<0.05), summarized gene-level variation was weakly associated with reduced risk (p-value=0.05), and the predominant haplotype was less common among cases than controls (0.36 v 0.40, p-value=0.05), consistent with single-SNP results.
conclusionTCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers. Follow-up molecular and replication studies are warranted.
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