ArticleCardiovascular diabetology2009
Relevance of hemostatic risk factors on coronary morphology in patients with diabetes mellitus type 2.
Article in Cardiovascular diabetology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.Scientific reports · 2016Pooled it
- Clinical significance of diabetes on symptom and patient delay among patients with acute myocardial infarction-an analysis from China Acute Myocardial Infarction (CAMI) registry.Journal of geriatric cardiology : JGC · 2019Article
- Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo.Cardiovascular diabetology · 2016Article
- Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction.Basic research in cardiology · 2014Article
- Does atorvastatin work more effectively than biguanides in reducing cardiovascular risk factors?Journal of pharmacy & bioallied sciences · 2011Article
- Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects.Cardiovascular diabetology · 2011Article
- Characterization of macro-and microvascular function and structure in patients with type 2 diabetes mellitus.American journal of cardiovascular disease · 2011Article
- Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2010Article
- Hemostatic risk factors in patients with coronary artery disease and type 2 diabetes - a two year follow-up of 243 patients.Cardiovascular diabetology · 2009Article
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4 authors.
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Abstract
objectiveThe influence hemostatitc parameters on the morphological extent and severity of coronary artery disease were studied in patients with and without DM type 2.
backgroundIt is known that patients with diabetes (DM) have abnormal metabolic and hemostatic parameters
methodsOf 150 consecutive patients with angiographically proven coronary artery disease 29 presented with DM. Additionally to parameters of lipid-metabolism fibrinogen, tissue-plasminogenactivator (t-PA), plasminogen-activator-inhibitor (PAI), plasmin-a-antiplasmin (PAP), prothrombin-fragment 1+2 (F1+2), thrombin-antithrombin (TAT), von-willebrand-factor (vWF), platelet factor 4 (PF4), glykomembranproteine 140 (GMP140) and the rheologic parameters plasma viscosity and red blood cell aggregation were evaluated. The extent and severity of CAD was evaluated according to the criteria of the American Heart Association.
resultsPatients with DM presented with a higher number of conventional risk factors as compared to non-diabetic patients. Additionally there were significant differences for F1+2, red blood cell aggregation and PAI. Diabetic patients showed a more severe extent of coronary arteriosclerosis, which also could be found more distally. A significant relationship between blood-glucose, thrombocyte-activation (vWF), endogenous fibrinolysis (PAI) and the severity of CAD and a more distal location of stenoses could be found (r = 0.6, p < 0.001).
conclusionPatients with coronary artery disease and DM type 2 showed marked alterations of metabolic, hemostatic, fibrinolytic and rheologic parameters, which can produce a prothrombogenic state. A direct association of thrombogenic factors on coronary morphology could be shown. This can be the pathophysiologic mechanism of more severe and distal pronounced coronary atherosclerosis in these patients.
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