ArticleThe Journal of comparative neurology2009
Neural reconnection in the transected spinal cord of the freshwater turtle Trachemys dorbignyi.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Involvement of vimentin- and BLBP-positive glial cells and their MMP expression in axonal regeneration after spinal cord transection in goldfish.Cell and tissue research · 2024Article
- The Neural Control Mechanisms of Gekkonid Adhesion Locomotion: The Effect of Spinal Cord Lesions.Biomimetics (Basel, Switzerland) · 2022Article
- Growth associated protein 43 and neurofilament immunolabeling in the transected lumbar spinal cord of lizard indicates limited axonal regeneration.Neural regeneration research · 2022Article
- Primary culture of adult cortical neurons from reptile Gekko japonicus.Journal of anatomy · 2021Article
- Regeneration in Reptiles Generally and the New Zealand Tuatara in Particular as a Model to Analyse Organ Regrowth in Amniotes: A Review.Journal of developmental biology · 2021Review
- Article
- Building bridges, not walls: spinal cord regeneration in zebrafish.Disease models & mechanisms · 2020Review
- Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury.Stem cells international · 2019Review
- Emergence of Serotonergic Neurons After Spinal Cord Injury in Turtles.Frontiers in neural circuits · 2018Article
- Gene Expression Profiling in the Injured Spinal Cord ofFrontiers in molecular neuroscience · 2017Article
- Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury.Experimental neurology · 2014Review
- Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander.Neuroscience bulletin · 2013Review
- Endogenous proliferation after spinal cord injury in animal models.Stem cells international · 2012Article
- Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells.Physiological reviews · 2011Review
- Cell proliferation and cytoarchitectural remodeling during spinal cord reconnection in the fresh-water turtle Trachemys dorbignyi.Cell and tissue research · 2011Article
- Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice.The Journal of comparative neurology · 2010Article
- Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This paper provides the first evidence that freshwater turtles are able to reconnect their completely transected spinal cords, leading to some degree of recovery of the motor functions lost after injury. Videographic analysis showed that some turtles (5 of 11) surviving more than 20 days after injury were able to initiate stepping locomotion. However, the stepping movements were slower than those of normal animals, and swimming patterns were not restored. Even though just 45% of the injured turtles recovered their stepping patterns, all showed axonal sprouting beyond the lesion site. Immunocytochemical and electron microscope images revealed the occurrence of regrowing axons crossing the severed region. A major contingent of the axons reconnecting the cord originated from sensory neurons lying in dorsal ganglia adjacent to the lesion site. The axons bridging the damaged region traveled on a cellular scaffold consisting of brain lipid-binding protein (BLBP)- and glial fibrillary acidic protein (GFAP)-positive cells and processes. Serotonergic varicose nerve fibers and endings were found at early stages of the healing process at the epicenter of the lesion. Interestingly, the glial scar commonly found in the damaged central nervous system of mammals was absent. In contrast, GFAP- and BLBP-positive processes were found running parallel to the main axis of the cord accompanying the crossing axons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.