ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Neural correlates of N-back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders.Psychiatry and clinical neurosciences · 2022Pooled it
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature.Neuroscience and biobehavioral reviews · 2016Pooled it
- Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies.Journal of psychiatry & neuroscience : JPN · 2012Pooled it
- Impaired visuospatial working memory but preserved attentional control in bipolar disorder.Psychological medicine · 2025Article
- Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study.BMC medicine · 2025Article
- Cognitive and neural abnormalities: working memory deficits in bipolar disorder offspring.Psychological medicine · 2025Article
- The characteristic of cognitive impairments in patients with bipolar II depression and its association with N-acetyl aspartate of the prefrontal white matter.Annals of translational medicine · 2020Article
- Aberrant brain network topology in fronto-limbic circuitry differentiates euthymic bipolar disorder from recurrent major depressive disorder.Brain and behavior · 2019Article
- Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder.Molecular psychiatry · 2018Article
- Behavioral and Neural Sustained Attention Deficits in Bipolar Disorder and Familial Risk of Bipolar Disorder.Biological psychiatry · 2017Article
- Effects of risk for bipolar disorder on brain function: A twin and family study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2017Article
- Disentangling Working Memory Functioning in Mood States of Bipolar Disorder: A Systematic Review.Frontiers in psychology · 2017Review
- Potential biomarkers for bipolar disorder: Where do we stand?The Indian journal of medical research · 2017Review
- Gray matter volumes in symptomatic and asymptomatic offspring of parents diagnosed with bipolar disorder.European child & adolescent psychiatry · 2016Article
- Connectomic markers of disease expression, genetic risk and resilience in bipolar disorder.Translational psychiatry · 2016Article
- The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information.NeuroImage. Clinical · 2016Article
- Prefrontal hypoactivation during working memory in bipolar II depression.Psychological medicine · 2015Article
- Shared and distinct neurocognitive endophenotypes of schizophrenia and psychotic bipolar disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2015Article
- All the world's a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective.Molecular psychiatry · 2015Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
First-degree relatives of persons with bipolar disorders (BDs) carry elevated risk for the illness, and manifest deficits in attention and memory (possible "endophenotypes"). However, there is only one published functional magnetic resonance imaging (fMRI) study of candidate endophenotypes in BD. We used fMRI to examine brain function in BD and in first-degree relatives performing a 2-back working memory (WM) task, and correlated brain activity with mood measures taken at the scanning session. Subjects (age 32-46) were 19 persons with BD, 18 unmedicated, non-psychotic first-degree relatives (RELs) of persons with BD, and 19 matched controls, ascertained from a long-term follow-up of a prenatal cohort study in New England. fMRI signal during 2-back and 0-back WM tasks was measured on a Siemens 1.5T MR scanner. fMRI data were analyzed using SPM-2. Persons with BD and RELs failed to suppress activation in the left anterior insula (BA 13) during WM, whereas controls suppressed activation. Compared to controls, RELs also failed to suppress activation in the orbitofrontal cortex (OFC) and superior parietal cortex. Controls and RELs exhibited greater activation than BD individuals in the left frontopolar cortex (BA 10) during WM. Results remained significant after controlling for confounders except for mild attenuation of OFC findings. Significant correlations between brain activity, mood, and WM suggest that activity in WM circuits is affected by activity in emotion-regulatory circuits. Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.