SynthesisPharmacoepidemiology and drug safety2009
The impact of medicinal drugs on traffic safety: a systematic review of epidemiological studies.
Synthesis in Pharmacoepidemiology and drug safety, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Medication use and the risk of motor vehicle collisions among licensed drivers: A systematic review.Accident; analysis and prevention · 2016Pooled it
- Young Drivers and Their Passengers: A Systematic Review of Epidemiological Studies on Crash Risk.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2015Pooled it
- Marijuana use and motor vehicle crashes.Epidemiologic reviews · 2012Pooled it
- Cognitive Expectancies for Hypnotic Use among Older Adult Veterans with Chronic Insomnia.Clinical gerontologistTrial
- Antidepressants and Road Safety: A Forensic Toxicological Perspective Based on Observational Data and Current Evidence.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.Exploratory research in clinical and social pharmacy · 2024Article
- Trends in the Use of Driving-Impairing Medicines According to the DRUID Category: A Population-Based Registry Study with Reference to Driving in a Region of Spain between 2015 and 2019.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Development and Validation of Questionnaires on Professional Drivers' Knowledge and Attitudes About Various Medications' Influence on Driving Ability.Zdravstveno varstvo · 2022Article
- Driving under the influence of drugs: Correlation between blood psychoactive drug concentrations and cognitive impairment. A narrative review taking into account forensic issues.Forensic science international. Synergy · 2022Review
- Article
- Medication use and driving patterns in older drivers: preliminary findings from the LongROAD study.Injury epidemiology · 2020Article
- Benzodiazepines in the oral fluid of Spanish drivers.Substance abuse treatment, prevention, and policy · 2020Article
- The relationship between illnesses and medical drug consumption with the occurrence of traffic accidents among truck and bus drivers in Tehran, Iran.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2019Article
- Prevalence of prescribed benzodiazepine long-term use in the French general population according to sociodemographic and clinical factors: findings from the CONSTANCES cohort.BMC public health · 2019Article
- Prescription opioids, alcohol and fatal motor vehicle crashes: a population-based case-control study.Injury epidemiology · 2019Article
- Prevalence of consumption of psychoactive substances amongst Moroccan taxi drivers.La Medicina del lavoro · 2018Observational
- Impact of Medical Conditions and Medications on Road Traffic Safety.Oman medical journal · 2018Article
- Work stress and health problems of professional drivers: a hazardous formula for their safety outcomes.PeerJ · 2018Article
- Observational
- Number of medications and adverse drug events by unintentional poisoning among older adults in consideration of inappropriate drug use: a Swedish population-based matched case-control study.European journal of clinical pharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the quality of epidemiological research into effects of medicinal drugs on traffic safety and the current knowledge in this area. DATA SOURCES: The bibliographic search was done in Medline electronic database using the keywords: ((accident* or crash*) and traffic and drug*) leading to 1141 references. Additional references were retrieved from the Safetylit website and the reference lists of selected studies. Original articles published in English or French, between 1 April 1979 and 31 July 2008, were considered for inclusion. We excluded descriptive studies, studies limited to alcohol or illicit drug involvement and investigations of injuries other than from traffic crashes. Studies based on laboratory tests, driving simulators or on-the-road driving tests were also excluded. Eligible studies had to evaluate the causal relationship between the use of medicinal drugs and the risk of traffic crashes. Study quality was assessed by two independent experts, according to a grid adapted from the strengthening the reporting of observational studies in epidemiology (STROBE) statement.
resultsTwenty two studies of variable methodological quality were included. Definition of drug exposure varied across studies and depended on the data sources. Potential confounding due to the interaction between the effects of the medicinal drug and disease-related symptoms was often not controlled. The risk of motor-vehicle crashes related to benzodiazepines has been amply studied and demonstrated. Results for other medicinal drugs remain controversial.
conclusionThere is a need for large studies, investigating the role of individual substances in the risk of road traffic crashes.
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