ArticleStem cells (Dayton, Ohio)2009
Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum.
Article in Stem cells (Dayton, Ohio), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
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- Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.PLoS biology · 2019Article
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- Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity.PLoS biology · 2018Article
- Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.The Journal of clinical investigation · 2018Article
- Consensus Paper: Cerebellar Development.Cerebellum (London, England) · 2016Review
- Alterations of Cell Proliferation and Apoptosis in the Hypoplastic Reeler Cerebellum.Frontiers in cellular neuroscience · 2016Article
- Heterogeneity and Bipotency of Astroglial-Like Cerebellar Progenitors along the Interneuron and Glial Lineages.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The Purkinje neuron: A central orchestrator of cerebellar neurogenesis.Neurogenesis (Austin, Tex.) · 2015Article
- GABAρ subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The role of stem cells and progenitors in the genesis of medulloblastoma.Experimental neurology · 2014Review
- Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.Neuron · 2014Article
- Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors.Developmental cell · 2013Article
- Hypoxia-induced developmental delays of inhibitory interneurons are reversed by environmental enrichment in the postnatal mouse forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Tracking cell lineage and fate into cerebellar circuits.Cerebellum (London, England) · 2012Article
- Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice.Brain research · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neural stem or progenitor cells (NSC/NPCs) able to generate the different neuron and glial cell types of the cerebellum have been isolated in vitro, but their identity and location in the intact cerebellum are unclear. Here, we use inducible Cre recombination in GFAPCreER(T2) mice to irreversibly activate reporter gene expression at P2 (postnatal day 2), P5, and P12 in cells with GFAP (glial fibrillary acidic protein) promoter activity and analyze the fate of genetically tagged cells in vivo. We show that cells tagged at P2-P5 with beta-galactosidase or enhanced green fluorescent proteins reporter genes generate at least 30% of basket and stellate GABAergic interneurons in the molecular layer (ML) and that they lose their neurogenic potential by P12, after which they generate only glia. Tagged cells in the cerebellar white matter (WM) were initially GFAP/S100beta+ and expressed the NSC/NPCs proteins LeX, Musashi1, and Sox2 in vivo. One week after tagging, reporter+ cells in the WM upregulated the neuronal progenitor markers Mash1, Pax2, and Gad-67. These Pax2+ progenitors migrated throughout the cerebellar cortex, populating the ML and leaving the WM by P18. These data suggest that a pool of GFAP/S100beta+ glial cells located in the cerebellar WM generate a large fraction of cerebellar interneurons for the ML within the first postnatal 12 days of cerebellar development. This restricted critical period implies that powerful inhibitory factors may restrict their fate potential in vivo at later stages of development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.