ArticleLab on a chip2009
Electrical detection of protein biomarkers using bioactivated microfluidic channels.
Article in Lab on a chip, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Automated Electrical Detection of Proteins for Oral Squamous Cell Carcinoma in an Integrated Microfluidic Chip Using Multi-Frequency Impedance Cytometry and Machine Learning.Sensors (Basel, Switzerland) · 2025Article
- Taguchi method: artificial neural network approach for the optimization of high-efficiency microfluidic biosensor for COVID-19.European physical journal plus · 2023Article
- A portable analog front-end system for label-free sensing of proteins using nanowell array impedance sensors.Scientific reports · 2022Article
- Development of Gold Nanoparticle Micropatterns for the Electrical Detection of Proteins.Nanomaterials (Basel, Switzerland) · 2021Article
- Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review.IEEE sensors journal · 2021Article
- Large-Scale Flow in Micro Electrokinetic Turbulent Mixer.Micromachines · 2020Article
- Tunable control of antibody immobilization using electric field.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Multiplexed actuation using ultra dielectrophoresis for proteomics applications: a comprehensive electrical and electrothermal design methodology.Lab on a chip · 2014Article
- Depletion of cells and abundant proteins from biological samples by enhanced dielectrophoresis.Sensors and actuators. B, Chemical · 2014Article
- Digital microfluidic assay for protein detection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Physiologically based pharmacokinetic models: integration of in silico approaches with micro cell culture analogues.Current drug metabolism · 2012Review
- An automated point-of-care system for immunodetection of staphylococcal enterotoxin B.Analytical biochemistry · 2011Article
- A microfluidic platform for electrical detection of DNA hybridization.Sensors and actuators. B, Chemical · 2011Article
- Recent advances in the MS analysis of glycoproteins: Capillary and microfluidic workflows.Electrophoresis · 2011Review
- Electrical Detection of Proteins and DNA using Bioactivated Microfluidic Channels: Theoretical and Experimental Considerations.Journal of vacuum science & technology. B, Microelectronics and nanometer structures : processing, measurement, and phenomena : an official journal of the American Vacuum Society · 2009Article
- A Microfluidic Platform for Characterization of Protein-Protein Interactions.IEEE sensors journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Current methods used for analyzing biomarkers involve expensive and time consuming techniques like the Sandwich ELISA which require lengthy incubation times, high reagent costs, and bulky optical equipment. We have developed a technique involving the use of a micro-channel with integrated electrodes, functionalized with receptors specific to target biomarkers. We have applied our biochip to the rapid electrical detection and quantification of target protein biomarkers using protein functionalized micro-channels. We successfully demonstrate detection of anti-hCG antibody, at a concentration of 1 ng ml(-1) and a dynamic range of three orders of magnitude, in less than one hour. We envision the use of this technique in a handheld device for multiplex high throughput analysis using an array of micro-channels for probing various protein biomarkers in clinically relevant samples such as human serum for cancer detection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.