ArticleBritish journal of cancer2009
Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2015Pooled it
- Influence of Height on Risk and Outcome of Patients with Early Breast Cancer: A Pooled Analysis of 4,925 Patients from 5 Randomized Trials of the Austrian Breast and Colorectal Cancer Study Group (ABCSG).Breast care (Basel, Switzerland) · 2022Article
- Fetal macrosomia, fetal insulin, and insulin-like growth factor- 1 among neonates in Lagos, Nigeria: A case-control study.PloS one · 2022Article
- The association of women's birth size with risk of molecular breast cancer subtypes: a cohort study.BMC cancer · 2021Article
- The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.European journal of epidemiology · 2019Article
- Breast cancer protection by genomic imprinting in close kin families.BMC medical genetics · 2017Review
- Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1.Cancer epidemiology · 2016Article
- Article
- Size at birth and risk of breast cancer: update from a prospective population-based study.European journal of epidemiology · 2015Article
- Maternal and cord blood hormones in relation to birth size.European journal of epidemiology · 2014Article
- Genetic and dietary determinants of insulin-like growth factor (IGF)-1 and IGF binding protein (BP)-3 levels among Chinese women.PloS one · 2014Article
- Measuring growth hormone and insulin-like growth factor-I in infants: what is normal?Pediatric endocrinology reviews : PER · 2013Review
- Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates.Cancer causes & control : CCC · 2012Article
- Prenatal modulation of breast density and breast stem cells by insulin-like growth factor-1.American journal of stem cells · 2012Article
- A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis.BMC cancer · 2011Article
- Height at diagnosis and birth-weight as risk factors for osteosarcoma.Cancer causes & control : CCC · 2011Article
- Maternal hormones during early pregnancy: a cross-sectional study.Cancer causes & control : CCC · 2010Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer incidence and birth weight are higher among Caucasian than Asian women, and birth size has been positively associated with breast cancer risk. Pregnancy hormone levels, however, have been generally lower in Caucasian than Asian women. We studied components of the insulin-like growth factor (IGF) system in cord blood from 92 singleton babies born in Boston, USA, and 110 born in Shanghai, China, in 1994-1995. Cord blood IGF-1 was significantly higher among Caucasian compared with Chinese babies (P<10(-6)). The opposite was noted for IGF-2 (P approximately 10(-4)). IGF-1 was significantly positively associated with birth weight and birth length in Boston, but not Shanghai. In contrast, stronger positive, though statistically non-significant, associations of IGF-2 with birth size were only evident in Shanghai. The associations of birth weight and birth length were positive and significant in taller women (for IGF-1 in Boston P approximately 0.003 and 0.03, respectively; for IGF-2 in Shanghai P approximately 0.05 and approximately 0.04, respectively), among whom maternal anthropometry does not exercise strong constraints in foetal growth. The documentation of higher cord blood levels of IGF-1, a principal growth hormone that does not cross the placenta, among Caucasian than in Asian newborns is concordant with breast cancer incidence in these populations.
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