The relative effects of paternal and maternal age in mongolism. 1933.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it.

1. First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.The Cochrane database of systematic reviews · 2017
   Pooled it
2. First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening.The Cochrane database of systematic reviews · 2017
   Pooled it
3. Urine tests for Down's syndrome screening.The Cochrane database of systematic reviews · 2015
   Pooled it
4. First trimester serum tests for Down's syndrome screening.The Cochrane database of systematic reviews · 2015
   Pooled it
5. Second trimester serum tests for Down's Syndrome screening.The Cochrane database of systematic reviews · 2012
   Pooled it
6. Association of Down's syndrome and water fluoride level: a systematic review of the evidence.BMC public health · 2001
   Pooled it
7. A prospective clinical trial to compare the performance of dried blood spots prenatal screening for Down's syndrome with conventional non-invasive testing technology.Experimental biology and medicine (Maywood, N.J.) · 2017
   Trial
8. Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026
   Review
9. Chromosomal Abnormalities in Miscarriages and Maternal Age: New Insights from the Study of 7118 Cases.Cells · 2024
   Article
10. Assessing the Influence of Maternal Age in Bovine Embryos and Oocytes: A Model for Human Reproductive Aging.Aging and disease · 2024
    Review
11. Biochemical Screening for Fetal Trisomy 21: Pathophysiology of Maternal Serum Markers and Involvement of the Placenta.International journal of molecular sciences · 2023
    Review
12. Are paternal or grandmaternal age associated with higher probability of trisomy 21 in offspring? A population-based, matched case-control study, 1995-2015.Paediatric and perinatal epidemiology · 2021
    Article
13. Advanced Parental Age at Conception and Sex Affects Mitochondrial DNA Copy Number in Human and Fruit Flies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
14. Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation.Brain imaging and behavior · 2019
    Article
15. Reproductive ageing-turning back the clock?Irish journal of medical science · 2019
    Review
16. Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome.Journal of Alzheimer's disease : JAD · 2018
    Article
17. Down Syndrome Screening in India: Are We There Yet?Journal of obstetrics and gynaecology of India · 2017
    Review
18. Tri-directional anaphases as a novel chromosome segregation defect in human oocytes.Human reproduction (Oxford, England) · 2017
    Article
19. Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.Molecular human reproduction · 2017
    Article
20. Paternal age and psychiatric disorders: A review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Review

Corrections and comments

• Commented on by
  Parental-age effects in Down syndrome.2009

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as