ArticleCancer research2009
Association between rectal optical signatures and colonic neoplasia: potential applications for screening.
Article in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence.Translational vision science & technology · 2019Article
- Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology.PloS one · 2019Article
- Optical study of chemotherapy efficiency in cancer treatment via intracellular structural disorder analysis using partial wave spectroscopy.Journal of biophotonics · 2018Article
- Optical pre-screening for laryngeal cancer using reflectance spectroscopy of the buccal mucosa.Biomedical optics express · 2018Article
- Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer.Clinical and translational gastroenterology · 2018Article
- The transformation of the nuclear nanoarchitecture in human field carcinogenesis.Future science OA · 2017Review
- Detection of precancerous lesions in the oral cavity using oblique polarized reflectance spectroscopy: a clinical feasibility study.Journal of biomedical optics · 2017Article
- Review of interferometric spectroscopy of scattered light for the quantification of subdiffractional structure of biomaterials.Journal of biomedical optics · 2017Review
- Article
- Aspirin and colorectal cancer: the promise of precision chemoprevention.Nature reviews. Cancer · 2016Review
- Fractal Characterization of Chromatin Decompaction in Live Cells.Biophysical journal · 2015Article
- Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa.Pancreas · 2015Article
- Field cancerisation in colorectal cancer: a new frontier or pastures past?World journal of gastroenterology · 2015Review
- Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Review
- Point-of-care and point-of-procedure optical imaging technologies for primary care and global health.Science translational medicine · 2014Review
- Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study.BMC cancer · 2014Article
- End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis.FEBS letters · 2014Article
- Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.Journal of biomedical optics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Field carcinogenesis detection represents a promising means for colorectal cancer (CRC) screening, although current techniques (e.g., flexible sigmoidoscopy) lack the requisite sensitivity. The novel optical technology low-coherence enhanced backscattering (LEBS) spectroscopy, allows identification of microscale architectural consequences of the field carcinogenesis in preclinical CRC models with unprecedented accuracy. To investigate the potential clinical translatability of this approach, we obtained biopsies from the normal-appearing rectal mucosa from patients undergoing colonoscopy (n = 219). LEBS signals were recorded through a bench-top instrument. Four parameters characterizing LEBS signal were linearly combined into a single marker. We found that LEBS signal parameters generally mirrored neoplasia progression from patients with no neoplasia, to 5 to 9 mm adenoma and to advanced adenomas. The composite LEBS marker calculated from the LEBS signal paralleled this risk status (ANOVA P < 0.001). Moreover, this was independent of CRC risk factors, benign colonic findings, or clinically unimportant lesions (diminutive adenomas, hyperplastic polyps). For advanced adenomas, the LEBS marker had a sensitivity of 100%, specificity of 80%, and area under the receiver operator characteristic curve of 0.895. Leave-one-out cross-validation and an independent data set (n = 51) supported the robustness of these findings. In conclusion, we provide the first demonstration that LEBS-detectable alterations in the endoscopically normal rectum were associated with the presence of neoplasia located elsewhere in the colon. This study provides the proof of concept that rectal LEBS analysis may potentially provide a minimally intrusive CRC screening technique. Further studies with an endoscopically compatible fiber optic probe are under way for multicenter clinical validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.