ArticleGenes & development2009
Chromatin-based transcriptional punctuation.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Determining Histone Posttranslational Modifications Along the Cell Cycle in Trypanosoma cruzi by Flow Cytometry.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes.Nature communications · 2025Article
- Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes.The Biochemical journal · 2025Review
- HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers.Nucleic acids research · 2023Article
- Alanine tRNAs Translate Environment Into Behavior inFrontiers in cell and developmental biology · 2020Article
- The epigenome of Trypanosoma brucei: a regulatory interface to an unconventional transcriptional machine.Biochimica et biophysica acta · 2014Review
- Parasite epigenetics and immune evasion: lessons from budding yeast.Epigenetics & chromatin · 2013Article
- Genomic organization of eukaryotic tRNAs.BMC genomics · 2010Article
- Histone variants--ancient wrap artists of the epigenome.Nature reviews. Molecular cell biology · 2010Review
- Article
- Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution.Biology direct · 2010Article
- Gene expression in trypanosomatid parasites.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The long polycistronic transcription units of trypanosomes do not appear to be demarcated by the usual DNA motifs that punctuate transcription in familiar eukaryotes. In this issue of Genes & Development, Siegel and colleagues (pp. 1063-1076) describe a system for the demarcation of trypanosome transcription units based on the deposition and turnover of histone variants rather than on the binding of transcription factors. Replication-independent incorporation of histone variants and destabilization of nucleosomes is an emerging theme at promoters of more familiar eukaryotes, and it now appears that this system is an evolutionarily conserved mode of transcriptional punctuation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.