ArticlePhysiological genomics2009
Foxa2-dependent hepatic gene regulatory networks depend on physiological state.
Article in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients.Scientific reports · 2025Article
- Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes.Cellular & molecular biology letters · 2025Review
- Article
- The role of FOXA family transcription factors in glucolipid metabolism and NAFLD.Frontiers in endocrinology · 2023Review
- The FOXA1 transcriptional network coordinates key functions of primary human airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Article
- Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.The Journal of cell biology · 2017Article
- Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site.Biochemistry · 2017Article
- Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation.Cell reports · 2014Article
- Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.The Journal of biological chemistry · 2014Article
- Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.Molecular metabolism · 2013Article
- Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.PLoS genetics · 2012Article
- Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues.Nucleic acids research · 2011Article
- The FoxA factors in organogenesis and differentiation.Current opinion in genetics & development · 2010Review
- Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.Genome research · 2010Article
- Genetic predictors of interindividual variability in hepatic CYP3A4 expression.The Journal of pharmacology and experimental therapeutics · 2010Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Bile acids are powerful detergents produced by the liver to aid in the absorption of dietary lipids. We recently reported a novel role for Foxa2 in bile acid metabolism. The winged helix transcription factor Foxa2 is required to prevent intrahepatic cholestasis and liver injury in mice fed a cholic acid-enriched diet. Here, we use functional genomics to study how Foxa2 regulates its targets in a cholic acid-dependent manner. We found that multiple signaling pathways essential for the hepatic response to acute liver injury are impaired in livers of Foxa2-deficient mice, suggesting that the deletion of Foxa2 in the hepatocyte affects the liver on a large scale. We also discovered distinct feed-forward regulatory loops controlling Foxa2-dependent targets in a cholic acid-dependent or -independent manner. We show that Foxa2 interacts with different transcription factors to achieve gene expression responses appropriate for each physiologic state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.