ArticleGenetics2009
Polymorphic genes of major effect: consequences for variation, selection and evolution in Arabidopsis thaliana.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Multiple solutions at the genomic level in response to selective breeding for high locomotor activity.Genetics · 2023Article
- Introduced populations of ragweed show as much evolutionary potential as native populations.Evolutionary applications · 2021Article
- Correlational selection in the age of genomics.Nature ecology & evolution · 2021Review
- Meiotic crossover reduction by virus-induced gene silencing enables the efficient generation of chromosome substitution lines and reverse breeding in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2020Article
- Rapid reversal of a potentially constraining genetic covariance between leaf and flower traits inEcology and evolution · 2020Article
- Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mapping of quantitative trait loci for life history traits segregating within common frog populations.Heredity · 2019Article
- Antagonistic selection and pleiotropy constrain the evolution of plant chemical defenses.Evolution; international journal of organic evolution · 2019Article
- Spatial difference in genetic variation for fenitrothion tolerance between local populations of Daphnia galeata in Lake Kasumigaura, Japan.Ecotoxicology (London, England) · 2017Article
- A Systems Genetics Approach Identifies Gene Regulatory Networks Associated with Fatty Acid Composition in Brassica rapa Seed.Plant physiology · 2016Article
- Environmentally induced changes in correlated responses to selection reveal variable pleiotropy across a complex genetic network.Evolution; international journal of organic evolution · 2015Article
- Quantitative Trait Locus Analysis of Seed Germination and Seedling Vigor in Brassica rapa Reveals QTL Hotspots and Epistatic Interactions.Frontiers in plant science · 2015Article
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- Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato.PloS one · 2013Article
- Floral genetic architecture: an examination of QTL architecture underlying floral (co)variation across environments.Genetics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of genes of major effect for evolutionary trajectories within and among natural populations has long been the subject of intense debate. For example, if allelic variation at a major-effect locus fundamentally alters the structure of quantitative trait variation, then fixation of a single locus can have rapid and profound effects on the rate or direction of subsequent evolutionary change. Using an Arabidopsis thaliana RIL mapping population, we compare G-matrix structure between lines possessing different alleles at ERECTA, a locus known to affect ecologically relevant variation in plant architecture. We find that the allele present at ERECTA significantly alters G-matrix structure-in particular the genetic correlations between branch number and flowering time traits-and may also modulate the strength of natural selection on these traits. Despite these differences, however, when we extend our analysis to determine how evolution might differ depending on the ERECTA allele, we find that predicted responses to selection are similar. To compare responses to selection between allele classes, we developed a resampling strategy that incorporates uncertainty in estimates of selection that can also be used for statistical comparisons of G matrices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.