ArticleProceedings of the National Academy of Sciences of the United States of America2009
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Exploration of the benefits and resistance mechanisms of immunotherapy based on PD-L1 expression, circulating tumor DNA and T-cell receptor profiles in advanced gastric cancer.Cancer immunology, immunotherapy : CII · 2025Article
- Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity.Immunologic research · 2024Article
- Comprehensive analysis of T cell receptor repertoire in patients withTranslational lung cancer research · 2022Article
- Profiling the peripheral blood T cell receptor repertoires of gastric cancer patients.Frontiers in immunology · 2022Article
- Characteristics of T-Cell Receptor Repertoire and Correlation WithFrontiers in oncology · 2021Article
- Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy.Frontiers in immunology · 2021Article
- Dynamic changes of T cell receptor repertoires in patients with hepatitis B virus-related acute-on-chronic liver failure.Hepatology international · 2020Article
- Determination of the complexity and diversity of the TCR β-chain CDR3 repertoire in bladder cancer using high-throughput sequencing.Oncology letters · 2019Article
- Dynamic Perturbations of CD4 and CD8 T Cell Receptor Repertoires in Chronic Hepatitis B Patients upon Oral Antiviral Therapy.Frontiers in immunology · 2017Article
- Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Identification of characteristic TRB V usage in HBV-associated HCC by using differential expression profiling analysis.Oncoimmunology · 2015Article
- Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice.Scientific reports · 2015Article
- Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- T cell receptor variable β gene repertoire in liver and peripheral blood lymphocytes of chronically hepatitis C virus-infected patients with and without mixed cryoglobulinaemia.Clinical and experimental immunology · 2013Article
- T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex.PLoS computational biology · 2012Article
- T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.Immunity · 2011Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We have hypothesized that in the prenegative selection TCR repertoire, many somatically generated complementary-determining region (CDR) 3 loops combine with evolutionarily selected germline Valpha/Vbeta CDR1/CDR2 loops to create highly MHC/peptide cross-reactive T cells that are subsequently deleted by negative selection. Here, we present a mutational analysis of the Vbeta CDR3 of such a cross-reactive T-cell receptor (TCR), YAe62. Most YAe62 TCRs with the mutant CDR3s became less MHC promiscuous. However, others with CDR3s unrelated in sequence to the original recognized even more MHC alleles than the original TCR. Most importantly, this recognition was still dependent on the conserved CDR1/CDR2 residues. These results bolster the idea that germline TCR V elements are inherently reactive to MHC but that this reactivity is fine-tuned by the somatically generated CDR3 loops.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.