ArticleProceedings of the National Academy of Sciences of the United States of America2009
Structure of the complex of a mitotic kinesin with its calcium binding regulator.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis.The Journal of cell biology · 2026Article
- Plant Kinesin Repertoires Expand with New Domain Architecture and Contract with the Loss of Flagella.Journal of molecular evolution · 2024Article
- Molecular chaperone Hsp90 protects KCBP from degradation by proteasome in Dunaliella salina cells.Folia microbiologica · 2021Article
- The AGCVIII kinase Dw2 modulates cell proliferation, endomembrane trafficking, and MLG/xylan cell wall localization in elongating stem internodes of Sorghum bicolor.The Plant journal : for cell and molecular biology · 2021Article
- Calcium Binding by Arabinogalactan Polysaccharides Is Important for Normal Plant Development.The Plant cell · 2020Article
- IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis.EMBO reports · 2020Article
- A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth.PLoS biology · 2019Article
- The preprophase band-associated kinesin-14 OsKCH2 is a processive minus-end-directed microtubule motor.Nature communications · 2018Article
- Method for the simulation of blood platelet shape and its evolution during activation.PLoS computational biology · 2018Article
- Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease.Molecular neurobiology · 2017Review
- Sorghum Dw2 Encodes a Protein Kinase Regulator of Stem Internode Length.Scientific reports · 2017Article
- The Cytoskeleton and Its Regulation by Calcium and Protons.Plant physiology · 2016Review
- Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines.Biophysical reviews · 2015Article
- Kar3Vik1 mechanochemistry is inhibited by mutation or deletion of the C terminus of the Vik1 subunit.The Journal of biological chemistry · 2013Article
- Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization.PloS one · 2013Article
- Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.The Journal of biological chemistry · 2012Article
- Crystallization and preliminary X-ray diffraction studies of the GhKCH2 motor domain: alteration of pH significantly improved the quality of the crystals.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Neck-motor interactions trigger rotation of the kinesin stalk.Scientific reports · 2012Article
- Hysteresis-based mechanism for the directed motility of the Ncd motor.Biophysical journal · 2011Article
- A seesaw model for intermolecular gating in the kinesin motor protein.Biophysical reviews · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Much of the transport, tension, and movement in mitosis depends on kinesins, the ATP-powered microtubule-based motors. We report the crystal structure of a kinesin complex, the mitotic kinesin KCBP bound to its principal regulator KIC. Shown to be a Ca(2+) sensor, KIC works as an allosteric trap. Extensive intermolecular interactions with KIC stabilize kinesin in its ADP-bound conformation. A critical component of the kinesin motile mechanism, called the neck mimic, switches its association from kinesin to KIC, stalling the motor. KIC denies access of the motor to its track by steric interference. Two major features of this regulation, allosteric trapping and steric blocking, are likely to be general for all kinesins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.