ArticleProceedings of the National Academy of Sciences of the United States of America2009
Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- RTF2 controls replication repriming and ribonucleotide excision at the replisome.Nature communications · 2024Article
- Article
- Article
- Mechanisms of direct replication restart at stressed replisomes.DNA repair · 2020Review
- Loss of the Nuclear Protein RTF2 Enhances Influenza Virus Replication.Journal of virology · 2020Article
- NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2.Oncogenesis · 2020Article
- Review
- Factors affecting template switch recombination associated with restarted DNA replication.eLife · 2019Article
- Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments.EMBO reports · 2018Review
- Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.Molecular cell · 2018Article
- Expression profile and in silico characterization of novel RTF2h gene under oxidative stress in Indian catfish, Clarias magur (Hamilton 1822).Molecular biology reports · 2017Article
- An Rtf2 Domain-Containing Protein Influences Pre-mRNA Splicing and Is Essential for Embryonic Development in Arabidopsis thaliana.Genetics · 2015Article
- Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.Nucleic acids research · 2015Article
- The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.PloS one · 2015Article
- Mechanism and physiological significance of programmed replication termination.Seminars in cell & developmental biology · 2014Review
- Impediments to replication fork movement: stabilisation, reactivation and genome instability.Chromosoma · 2013Review
- Article
- Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.PloS one · 2013Article
- Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier.Nucleic acids research · 2011Article
- Maintaining genome stability at the replication fork.Nature reviews. Molecular cell biology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we identify a phylogenetically conserved Schizosaccharomyces pombe factor, named Rtf2, as a key requirement for efficient replication termination at the site-specific replication barrier RTS1. We show that Rtf2, a proliferating cell nuclear antigen-interacting protein, promotes termination at RTS1 by preventing replication restart; in the absence of Rtf2, we observe the establishment of "slow-moving" Srs2-dependent replication forks. Analysis of the pmt3 (SUMO) and rtf2 mutants establishes that pmt3 causes a reduction in RTS1 barrier activity, that rtf2 and pmt3 are nonadditive, and that pmt3 (SUMO) partly suppresses the rtf2-dependent replication restart. Our results are consistent with a model in which Rtf2 stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.