Evidence map›Paper›PMID 19416535›Full record

ArticleBMC bioinformatics2009

Willows: a memory efficient tree and forest construction package.

Heping Zhang, Minghui Wang, Xiang Chen

Abstract read
In one paragraph

Article in BMC bioinformatics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heping ZhangDepartment of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. heping.zhang@yale.edu
Minghui Wang
Xiang Chen

Funding

Statistical Methods in Genetic Studies of Substance UseR01DA016750 · NIDA · YALE UNIVERSITY · PI ZHANG, HEPING · 2004 to 2016
$3.3M
Methodological Research on Substance UseK02DA017713 · NIDA · YALE UNIVERSITY · PI ZHANG, HEPING · 2004 to 2008
$750k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
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NHLBI NIH HHS N01 HC025195NIDA NIH HHS K02 DA017713NIDA NIH HHS R01 DA016750
6 · The paper itself

Abstract

backgroundExisting tree and forest methods are powerful bioinformatics tools to explore high dimensional data including high throughput genomic data. However, they cannot deal with the data generated by recent genotyping platforms for single nucleotide polymorphisms due to the massive size of the data and its excessive memory demand.

resultsUsing the recursive partitioning technique, we developed a new software package, Willows, to maximize the utility of the computer memory and make it feasible to analyze massive genotype data. This package includes three tree-based methods -- classification tree, random forest, and deterministic forest, and can efficiently handle the massive amount of SNP data. In addition, this package can easily set different options (e.g., algorithms and specifications) and predict the class of test samples.

conclusionWe developed Willows in a user friendly interface with the goal of maximizing the use of memory, which is critical for analysis of genomic data. The Willows package is well documented and publicly available at (http://c2s2.yale.edu/software/Willows).

Indexed as

SoftwareComputational BiologyGenome-Wide Association StudyPolymorphism, Single Nucleotide

Identifiers

PMID19416535
PMCPMC2683818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.