ReviewTraffic (Copenhagen, Denmark)2009
Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses.
Review in Traffic (Copenhagen, Denmark), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Immune-related actinopathies at the cross-road of immunodeficiency, autoimmunity and autoinflammation.Nature reviews. Immunology · 2026Review
- Gene expression analyses reveal differences in children's response to malaria according to their age.Nature communications · 2024Article
- Gene expression analyses reveal differences in children's response to malaria according to their age.bioRxiv : the preprint server for biology · 2023Article
- Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes.Journal of extracellular vesicles · 2020Article
- Inducible Polarized Secretion of Exosomes in T and B Lymphocytes.International journal of molecular sciences · 2020Review
- Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set.Frontiers in immunology · 2016Review
- Modulation of Igβ is essential for the B cell selection in germinal center.Scientific reports · 2015Article
- Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.Journal of cell science · 2015Article
- B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions.Frontiers in immunology · 2015Review
- Article
- How B cells capture, process and present antigens: a crucial role for cell polarity.Nature reviews. Immunology · 2013Review
- LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency.The Journal of allergy and clinical immunology · 2012Article
- Tight junction proteins expression and modulation in immune cells and multiple sclerosis.Journal of cellular and molecular medicine · 2012Article
- Article
- Cytoskeletal polarity mediates localized induction of the heart progenitor lineage.Nature cell biology · 2011Article
- Receptor-mediated T cell absorption of antigen presenting cell-derived molecules.Frontiers in bioscience (Landmark edition) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The onset of an adaptive immune response requires the activation of T and B lymphocytes by antigen-presenting cells, through a specialized form of intercellular communication, known as the immunological synapse (IS). In B lymphocytes the IS promotes efficient recognition and acquisition of membrane-bound Ags, while in T cells, it modulates the T cell response upon exposure to peptide-major histocompatibility complexes. In this review, we highlight the similarities that determine B and T cell activation, focusing on immune receptor downstream signaling events that lead to synapse formation. We stress the notion that polarization of T and B lymphocytes characterized by global changes in cytoskeleton and membrane trafficking modulates synapse structure and function, thus determining lymphocyte effector functions and fate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.