ReviewAlimentary pharmacology & therapeutics2009
Review article: adherence to medication for chronic hepatitis C - building on the model of human immunodeficiency virus antiretroviral adherence research.
Review in Alimentary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02740556 (Evaluation of HepCure Toolkit to Improve Harvoni Adherence), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of HepCure Toolkit to Improve Harvoni Adherence
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recommendations for the management of hepatitis C virus infection among people who inject drugs.The International journal on drug policy · 2015Guideline
- Nonadherence to Ledipasvir/Sofosbuvir Did Not Predict Sustained Virologic Response in a Randomized Controlled Trial of Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Persons Who Use Drugs.The Journal of infectious diseases · 2022Trial
- Adherence to response-guided pegylated interferon and ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: the ACTIVATE study.BMC infectious diseases · 2017Trial
- Rationale and design of a randomized controlled trial of directly observed hepatitis C treatment delivered in methadone clinics.BMC infectious diseases · 2011Trial
- Adherence to treatment for recently acquired hepatitis C virus (HCV) infection among injecting drug users.Journal of hepatology · 2011Trial
- Wirelessly Observed Therapy to Optimize Adherence and Target Interventions for Oral Hepatitis C Treatment: Observational Pilot Study.Journal of medical Internet research · 2020Article
- Psychosocial and Neurocognitive Factors Associated With Hepatitis C - Implications for Future Health and Wellbeing.Frontiers in psychology · 2018Review
- Greater decline in memory and global neurocognitive function in HIV/hepatitis C co-infected than in hepatitis C mono-infected patients treated with pegylated interferon and ribavirin.Journal of neurovirology · 2017Article
- The Australasian Hepatology Association consensus guidelines for the provision of adherence support to patients with hepatitis C on direct acting antivirals.Patient preference and adherence · 2016Article
- Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection.PLoS computational biology · 2015Article
- Correlates of Initiation of Treatment for Chronic Hepatitis C Infection in United States Veterans, 2004-2009.PloS one · 2015Article
- Patient adherence issues in the treatment of hepatitis C.Patient preference and adherence · 2014Review
- Factors associated with uptake, adherence, and efficacy of hepatitis C treatment in people who inject drugs: a literature review.Patient preference and adherence · 2013Review
- Adherence to PEG/ribavirin treatment for chronic hepatitis C: prevalence, patterns, and predictors of missed doses and nonpersistence.Journal of viral hepatitis · 2013Article
- High effectiveness of peginterferon alfa-2a plus ribavirin therapy in Korean patients with chronic hepatitis C in clinical practice.Clinical and molecular hepatology · 2013Article
- Adherence to chronic hepatitis C treatment regimen: first report from a referral center in iran.Hepatitis monthly · 2013Article
- Anemia management in the era of triple combination therapy for chronic HCV.Gastroenterology & hepatology · 2012Article
- Evaluation of adherence to oral antiviral hepatitis B treatment using structured questionnaires.World journal of hepatology · 2012Article
- Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study.Annals of internal medicine · 2011Article
- Adherence during antiviral treatment regimens for chronic hepatitis C: a qualitative study of patient-reported facilitators and barriers.Journal of clinical gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTreatment of hepatitis C virus (HCV) infection with pegylated interferon/ribavirin achieves sustained virological response in up to 56% of HCV mono-infected patients and 40% of HCV/human immunodeficiency virus (HIV)-co-infected patients. The relationship of patient adherence to outcome warrants study.
aimTo review comprehensively research on patient-missed doses to HCV treatment and discuss applicable research from adherence to HIV antiretroviral therapy.
methodsPublications were identified by PubMed searches using the keywords: adherence, compliance, hepatitis C virus, interferon and ribavirin.
resultsThe term 'non-adherence' differs in how it is used in the HCV from the HIV literature. In HCV, 'non-adherence' refers primarily to dose reductions by the clinician and early treatment discontinuation. In contrast, in HIV, 'non-adherence' refers primarily to patient-missed doses. Few data have been published on the rates of missed dose adherence to pegylated interferon/ribavirin and its relationship to virological response.
conclusionsAs HCV treatment becomes more complex with new classes of agents, adherence will be increasingly important to treatment success as resistance mutations may develop with suboptimal dosing of HCV enzyme inhibitors. HIV adherence research can be applied to that on HCV to establish accurate methods to assess adherence, investigate determinants of non-adherence and develop strategies to optimize adherence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.