ReviewFuture microbiology2009
Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria.
Review in Future microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Drug resistance of Plasmodium falciparum and Plasmodium vivax isolates in Indonesia.Malaria journal · 2022Pooled it
- Aspartyl protease inhibition interferes with Plasmodium falciparum asexual blood-stage and early gametocyte development.Malaria journal · 2025Article
- Population dynamics and drug resistance mutations in Plasmodium falciparum on the Bijagós Archipelago, Guinea-Bissau.Scientific reports · 2023Article
- Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases.Nutrients · 2022Review
- Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Pathogens (Basel, Switzerland) · 2022Article
- Prevalence of malaria resistance-associated mutations inFrontiers in microbiology · 2022Article
- Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy againstBioactive materials · 2021Article
- A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.British journal of pharmacology · 2021Article
- Drug resistance in protozoan parasites.Emerging topics in life sciences · 2017Article
- Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells.Cancer cell international · 2017Article
- Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Molecular biology and evolution · 2016Article
- Article
- Molecular markers of anti-malarial drug resistance in southwest Ethiopia over time: regional surveillance from 2006 to 2013.Malaria journal · 2015Article
- Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- High prevalence of pfmdr1 N86Y and Y184F mutations in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea.Pathogens and global health · 2014Article
- Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.Antimicrobial agents and chemotherapy · 2014Article
- Genetics of chloroquine-resistant malaria: a haplotypic view.Memorias do Instituto Oswaldo Cruz · 2013Review
- Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.Antimicrobial agents and chemotherapy · 2013Article
- Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis.Malaria journal · 2013Article
- Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.Antimicrobial agents and chemotherapy · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
30 years before the discovery of the pfcrt gene, altered cellular drug accumulation in drug-resistant malarial parasites had been well documented. Heme released from catabolized hemoglobin was thought to be a key target for quinoline drugs, and additional modifications to quinoline drug structure in order to improve activity against chloroquine-resistant malaria were performed in a few laboratories. However, parasite cell culture methods were still in their infancy, assays for drug susceptibility were not well standardized, and the power of malarial genetics was decades away. The last 10 years have witnessed explosive progress in elucidation of the biochemistry of chloroquine resistance. This review briefly summarizes that progress, and discusses where additional work is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.