ArticleHepatology (Baltimore, Md.)2009
Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.
Article in Hepatology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Novel Insights on the Use of L-Asparaginase as an Efficient and Safe Anti-Cancer Therapy.Cancers · 2022Review
- Molecular pathology endpoints useful for aging studies.Ageing research reviews · 2017Review
- MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells.Biochimica et biophysica acta · 2015Article
- Article
- Comparative analysis reveals similarities between cultured submandibular salivary gland cells and liver progenitor cells.SpringerPlus · 2014Article
- Asparagine synthetase: regulation by cell stress and involvement in tumor biology.American journal of physiology. Endocrinology and metabolism · 2013Review
- ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation.The Journal of biological chemistry · 2012Article
- The transcription factor network associated with the amino acid response in mammalian cells.Advances in nutrition (Bethesda, Md.) · 2012Review
- Fork head transcription factor is required for ovarian mature in the brown planthopper, Nilaparvata lugens (Stål).BMC molecular biology · 2011Article
- Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway.The Journal of biological chemistry · 2011Article
- Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium.Amino acids · 2011Article
- Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells.Physiological genomics · 2010Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The FOXA (forkhead box A) proteins (FOXA1, FOXA2, and FOXA3) play a critical role in the development of the liver, and they also regulate metabolism in adult hepatic tissue. The liver responds to changes in nutrient availability by initiating a number of stress signaling pathways. The present studies demonstrated that in mouse dams fed a low-protein diet hepatic expression of FOXA2 and FOXA3 messenger RNA, but not FOXA1, was induced. Conversely, fetal liver did not exhibit this regulation. Amino acid deprivation of HepG2 hepatoma cells also enhanced transcription from the FOXA2 and FOXA3 genes. In contrast, endoplasmic reticulum stress inhibited the expression of FOXA1, only slightly induced FOXA2, and had no effect on FOXA3. The FOXA2 and FOXA3 messenger RNA induction by amino acid deprivation did not require activating transcription factor 4, a critical component of the conventional amino acid response (AAR) pathway, but their induction was partially dependent on CCAAT/enhancer-binding protein beta. Simultaneous knockdown of both FOXA2 and FOXA3 by small interfering RNA did not affect the activation of other amino acid responsive genes, suggesting that the FOXA proteins are not required for the known AAR pathway. Collectively, the results document that the hepatic FOXA family of genes are differentially regulated by amino acid availability.
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