ArticleSleep & breathing = Schlaf & Atmung2009
Pro-atherogenic cytokine profile of patients with suspected obstructive sleep apnea.
Article in Sleep & breathing = Schlaf & Atmung, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The serum YKL-40 level is a potential biomarker for OSAHS: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Sleep Apnea Indices Associated with Markers of Inflammation and Cardiovascular Disease: A Proteomic Study in the MUSTACHE Cohort.Annals of the American Thoracic Society · 2024Article
- Evaluation of preoperative and postoperative serum interleukin-6, interleukin-8, tumor necrosis factor α and raftlin levels in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2021Article
- Article
- Adhesion molecule gene variants and plasma protein levels in patients with suspected obstructive sleep apnea.PloS one · 2019Article
- Obstructive Sleep Apnea: From Intermittent Hypoxia to Cardiovascular Complications via Blood Platelets.Frontiers in neurology · 2018Review
- The role inflammatory response genes in obstructive sleep apnea syndrome: a review.Sleep & breathing = Schlaf & Atmung · 2016Review
- [Association of sleep-disordered breathing and malignant arrhythmias in patients with ischemic and dilated cardiomyopathy].Herzschrittmachertherapie & Elektrophysiologie · 2015Review
- Association of serum hepcidin levels with the presence and severity of obstructive sleep apnea syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study.International journal of obesity (2005) · 2013Article
- Analysis of systemic and airway inflammation in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2013Article
- Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury.Sleep & breathing = Schlaf & Atmung · 2013Article
- Pathophysiologic mechanisms of cardiovascular disease in obstructive sleep apnea syndrome.Pulmonary medicine · 2013Article
- Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS).Sleep & breathing = Schlaf & Atmung · 2010Review
- Sleep Disordered Breathing and the Pathogenesis of Atrial Fibrillation.Journal of atrial fibrillationReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeSystemic inflammation is important in the pathogenesis of cardiovascular disease (CVD). We sought to characterize the systemic inflammatory profile associated with obstructive sleep apnea (OSA).
methodsAdult patients referred for suspected OSA at the University of British Columbia Hospital Sleep Disorders Program were recruited for our study. Patients using HMG CoA inhibitors or a history of CVD were excluded. Fasting serum samples were obtained the morning after their diagnostic polysomnograms. Samples were tested for the following circulating inflammatory mediators: interferon gamma; interleukins 1B, 6, and 8; intercellular and vascular cell adhesion molecules (sICAM-1 and sVCAM-1); and leptin using a multiplex Luminex System.
resultsThere were 176 patients; 68% were male, mean age = 50 +/- (SD) 11 years, mean apnea/hyponea index (AHI) = 22.9 +/- 22/h, mean desaturation (i.e. % of sleep time spent below an oxyhemoglobin saturation of 90%) = 5.4% +/- 15, and mean body mass index (BMI) = 32.2 +/- 8 kg/m(2). In univariate analyses, only leptin, sVCAM-1, and sICAM-1 were significantly associated with indices of OSA severity (i.e. AHI and/or desaturation). In multivariate linear regression analyses that controlled for BMI, gender, age, and current smoking; desaturation persisted as a significant independent predictor for elevated sVCAM-1 and leptin.
conclusionsWe did not find significant associations between OSA and markers of activated innate immunity (IL-1B, 6, and 8). However, OSA severity was independently associated with serum levels of sVCAM-1 and leptin; these may represent mechanisms involved in the pathogenesis of OSA-related CVD.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.