ReviewSeminars in immunopathology2009
CRP and the risk of atherosclerotic events.
Review in Seminars in immunopathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies.Journal of human hypertension · 2021Pooled it
- C-reactive protein-albumin-lymphocyte (CALLY) index and all-cause and cardiovascular mortality in the general population: a national health and nutrition examination survey analysis.Journal of cardiothoracic surgery · 2026Article
- Association of C-reactive protein-albumin-lymphocyte index and coronary artery calcification on major adverse cardiovascular events of dialysis patients with acute coronary syndrome.Frontiers in immunology · 2026Article
- Serum ferritin is a superior biomarker for evaluating disease activity and kidney injury compared with C-reactive protein in anti-neutrophil cytoplasmic antibody-associated vasculitis.Clinical rheumatology · 2025Article
- Time Course of Plasma Proteomic and Oxylipin Changes Induced by LPS Challenge and Modulated by Antioxidant Supplementation in a Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2025Article
- Expression of nucleotide-binding oligomerization domain-like receptor protein 1 in patients with acute myocardial infarction and its relationship with clinical prognosis.Frontiers in cardiovascular medicine · 2025Article
- Soluble endoglin as a biomarker of successful rheopheresis treatment in patients with age-related macular degeneration.Scientific reports · 2024Article
- Comparison of the stability of glycoprotein acetyls and high sensitivity C-reactive protein as markers of chronic inflammation.Immunology · 2024Review
- Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.BMC geriatrics · 2024Article
- Disease-associated metabolic pathways affected by heavy metals and metalloid.Toxicology reports · 2023Review
- The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database.Frontiers in nutrition · 2023Article
- Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks.Scientific reports · 2022Article
- Antibodies towards TVLLPVIFF Amino Acid Sequence of TNF Receptor Induced byJournal of clinical medicine · 2022Article
- Statins and Inflammation.Current atherosclerosis reports · 2021Review
- Post-traumatic stress disorder and its association with stroke and stroke risk factors: A literature review.Neurobiology of stress · 2021Review
- The inflammation link between periodontal disease and coronary atherosclerosis in patients with acute coronary syndromes: case-control study.BMC oral health · 2021Article
- TMT-Based Plasma Proteomics Reveals Dyslipidemia Among Lowlanders During Prolonged Stay at High Altitudes.Frontiers in physiology · 2021Article
- Dietary Inflammatory Index Is Associated With Inflammation in Japanese Men.Frontiers in nutrition · 2021Article
- C-reactive protein and cardiovascular disease: From animal studies to the clinic (Review).Experimental and therapeutic medicine · 2020Review
- Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large body of literature supports the idea that inflammation plays a pivotal role in all phases of atherosclerosis, from the fatty streak lesion formation to the acute coronary event due to vulnerable plaque rupture. Indeed, vascular inflammation contributes to the pathogenesis of atherosclerosis, and later in the disease process, it is a major determinant for the acute coronary syndromes. There are various inflammatory markers that have been shown to predict cardiovascular events. These include high-sensitivity C-reactive protein (hs-CRP), a simple downstream marker of inflammation, recently emerged as a major cardiovascular risk factor. Elevated baseline concentrations of hs-CRP are associated with the risk of atherosclerotic events in general populations and show a predictive value even in terms of secondary prevention, both in patients with chronic stable angina and acute coronary syndromes. In recent year, a lot of concerns have emerged about the experimental models used to study the role of CRP in atherosclerosis; moreover, the results of trials evaluating the clinical association between this molecules and outcome are still controversial. In this paper, we attempt to review the pathophysiological evidences about the link between CRP and atherosclerosis and, most notably, about its utility as a marker and risk predictor in various clinical settings. The identification of specific triggers and mechanisms of underlying inflammation and a better understanding of each step involved in this complex process might lead to new ways to manage patients with atherosclerosis, both in terms of primary and secondary prevention, and CRP still appears to be a suitable candidate for this purpose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.