ArticleJournal of materials science. Materials in medicine2009
Nucleation and growth of calcium phosphates in the presence of fibrinogen on titanium implants with four potentially bioactive surface preparations. An in vitro study.
Article in Journal of materials science. Materials in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 22 citations in OpenAlex.
- The Significance and Utilisation of Biomimetic and Bioinspired Strategies in the Field of Biomedical Material Engineering: The Case of Calcium Phosphat-Protein Template Constructs.Materials (Basel, Switzerland) · 2020Review
- The effect of hydroxyapatite nanocrystals on osseointegration of titanium implants: an in vivo rabbit study.International journal of dentistry · 2014Article
- Article
- Precipitation of Calcium Phosphates in the Presence of Collagen Type I on Four Different Bioactive Titanium Surfaces: an in Vitro Study.Journal of oral & maxillofacial researchArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to compare the nucleating and crystal growth behaviour of calcium phosphates on four types of potentially bioactive surfaces, using the simulated body fluid (SBF) model with added fibrinogen. Blasted titanium discs were modified by alkali and heat treatment, anodic oxidation, fluoride treatment, or hydroxyapatite coating. The discs were immersed in SBF with fibrinogen for periods of 3 days and 1, 2, 3 and 4 weeks. The topography, morphology, and chemistry of the surfaces were evaluated with optical interferometry, scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDX), and x-ray photoelectron spectroscopy (XPS), respectively. All surface modifications showed early calcium phosphate formation after 3 days, and were almost completely covered by calcium phosphates after 2 weeks. After 4 weeks, the Ca/P ratio was approximately 2.0 for all surface groups except the fluoride modified surface, which had a Ca/P ratio of 1.0-1.5. XPS measurements of the nitrogen concentration, which can be interpreted as an indirect measure of the protein content, reached a peak value after 3 days immersion and decreased thereafter. In conclusion, the results in the present study, when compared to earlier SBF studies without proteins, showed that fibrinogen stimulates calcium phosphates formation. Furthermore, no pronounced differences could be detected between blasted controls and the potentially bioactive specimens.
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