ArticleThe open medical informatics journal2008
The impact of parameter identification methods on drug therapy control in an intensive care unit.
Article in The open medical informatics journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control.Annals of intensive care · 2012Article
- Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice?Annals of intensive care · 2011Article
- Validation of a model-based virtual trials method for tight glycemic control in intensive care.Biomedical engineering online · 2010Article
- What makes tight glycemic control tight? The impact of variability and nutrition in two clinical studies.Journal of diabetes science and technology · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper investigates the impact of fast parameter identification methods, which do not require any forward simulations, on model-based glucose control, using retrospective data in the Christchurch Hospital Intensive Care Unit. The integral-based identification method has been previously clinically validated and extensively applied in a number of biomedical applications; and is a crucial element in the presented model-based therapeutics approach. Common non-linear regression and gradient descent approaches are too computationally intense and not suitable for the glucose control applications presented. The main focus in this paper is on better characterizing and understanding the importance of the integral in the formulation and the effect it has on model-based drug therapy control. As a comparison, a potentially more natural derivative formulation which has the same computation speed advantages is investigated, and is shown to go unstable with respect to modelling error which is always present clinically. The integral method remains robust.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.